Rational design of highly active sgRNAs for CRISPR-Cas9–mediated gene inactivation
John G. Doench(Broad Institute), Ella Hartenian(Broad Institute), Daniel B. Graham(Broad Institute), Zuzana Tóthová(Broad Institute), Mudra Hegde(Broad Institute), Ian C. P. Smith(Broad Institute), Meagan E. Sullender(Broad Institute), Benjamin L. Ebert(Broad Institute), Ramnik J. Xavier(Massachusetts General Hospital), David E. Root(Broad Institute)
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Abstract
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