Specific Inhibition of Nuclear RNA Polymerase II by α-Amanitin
Thomas J. Lindell(University of California, San Francisco), Fanyela Weinberg(University of California, San Francisco), Paul W. Morris(University of California, San Francisco), Robert G. Roeder(University of California, San Francisco), William J. Rutter(University of California, San Francisco)
Cited by 867
Abstract
alpha-Amanitin, a toxic substance from the mushroom Amanita phalloides, is a potent inhibitor of DNA-dependent RNA polymerase II (the nucleoplasmic form) from sea urchin, rat liver, and calf thymus. This compound exerts no effect on the activity of polymerase I (nucleolar form) or polymerase III (also nucleoplasmic). The inhibition is due to a specific interaction with polymerase II or with a complex of DNA and polymerase II.
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