Accelerated epigenetic aging in Down syndrome
Steve Horvath(University of California, Los Angeles), Paolo Garagnani(IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola), Maria Giulia Bacalini(University of Bologna), Chiara Pirazzini(University of Bologna), Stefano Salvioli(University of Bologna), Davide Gentilini(IRCCS Istituto Auxologico Italiano), Anna Maria Di Blasio(IRCCS Istituto Auxologico Italiano), Cristina Giuliani(University of Bologna), Spencer Tung(University of California, Los Angeles), Harry V. Vinters(University of California, Los Angeles), Claudio Franceschi(Institute of Neurological Sciences)
Cited by 521Open Access
Abstract
Down Syndrome (DS) entails an increased risk of many chronic diseases that are typically associated with older age. The clinical manifestations of accelerated aging suggest that trisomy 21 increases the biological age of tissues, but molecular evidence for this hypothesis has been sparse. Here, we utilize a quantitative molecular marker of aging (known as the epigenetic clock) to demonstrate that trisomy 21 significantly increases the age of blood and brain tissue (on average by 6.6 years, P = 7.0 × 10(-14)).
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