Both CD28 ligands CD80 (B7-1) and CD86 (B7-2) activate phosphatidylinositol 3-kinase, and wortmannin reveals heterogeneity in the regulation of T cell IL-2 secretion
Yuji Ueda(Naval Medical Research Command), Stephen G. Ward(University of Bath), Carl H. June(Parker Institute for Cancer Immunotherapy), Gordon J. Freeman(Harvard University), Mark Huang(Naval Medical Research Command), Bruce L. Levine(Parker Institute for Cancer Immunotherapy), Lee M. Nadler(Dana-Farber Cancer Institute)
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