Synthesis and Preliminary Biological Studies of 3-Substituted Indoles Accessed by a Palladium-Catalyzed Enantioselective Alkene Difunctionalization Reaction
Tejas P. Pathak(Huntsman Cancer Institute), Keith M. Gligorich(Huntsman Cancer Institute), Bryan E. Welm(University of Utah), Matthew S. Sigman(University of Utah)
Cited by 234
Abstract
A unique alkene difunctionalization reaction that allows rapid construction of molecular complexity around the biologically relevant indole framework has been developed. The reaction proceeds with up to 87% yield, 99:1 er, and >20:1 dr. Evaluation of several of the compounds revealed promising anticancer activity against MCF-7 cells.
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