Liver Fluke Induces Cholangiocarcinoma

Banchob Sripa; Sasithorn Kaewkes; Paiboon Sithithaworn; Eimorn Mairiang; Thewarach Laha; Michael J. Smout; Chawalit Pairojkul; Vajaraphongsa Bhudhisawasdi; Smarn Tesana; Bandit Thinkamrop; Jeffrey M. Bethony; Alex Loukas; Paul J. Brindley

doi:10.1371/journal.pmed.0040201

Liver Fluke Induces Cholangiocarcinoma

Banchob Sripa(Khon Kaen University), Sasithorn Kaewkes(George Washington University), Paiboon Sithithaworn(Tulane University), Eimorn Mairiang(George Washington University), Thewarach Laha(Tulane University), Michael J. Smout(Tulane University), Chawalit Pairojkul(Tulane University), Vajaraphongsa Bhudhisawasdi(Tulane University), Smarn Tesana(George Washington University), Bandit Thinkamrop(George Washington University), Jeffrey M. Bethony(Tulane University), Alex Loukas(George Washington University), Paul J. Brindley(Tulane University)

PLoS Medicine

July 3, 2007

10.1371/journal.pmed.0040201

Cited by 767Open Access

Full Text

Abstract

The authors discuss the molecular pathogenesis of opisthorchiasis and associated cholangiocarcinogenesis, particularly nitrative and oxidative DNA damage and the clinical manifestations of cholangiocarcinoma.

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