Localization and Sequence Analysis of Yeast Origins of DNA Replication
James R. Broach(Stony Brook University), Y.-Y. Li(Stony Brook University), J. Feldman(Cold Spring Harbor Laboratory), Makkuni Jayaram(Cold Spring Harbor Laboratory), Jacinth Abraham(Cold Spring Harbor Laboratory), Kim Nasmyth(Cold Spring Harbor Laboratory), James Hicks(State University of New York)
Cited by 371
Abstract
The precise and uniform duplication of a cell's genome is essential to its normal growth. Focal points for the orchestration of this central process are provided by specific loci within the genome that function as sites of initiation of DNA replication. In this paper we present results that allow us to address the structural characteristics of DNA replication origins in yeast.
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