In vivo imaging and evaluation of different biomatrices for improvement of stem cell survival
Feng Cao(Stanford Medicine), Amir H Sadrzadeh Rafie(Stanford Medicine), Oscar J. Abilez(Stanford University), Haichang Wang(Xijing Hospital), Jennifer T. Blundo(Stanford University), Beth L. Pruitt(Stanford University), Christopher K. Zarins(Stanford University), Joseph C. Wu(Stanford University)
Cited by 38
Abstract
Therapeutic effects from injection of stem cells are often hampered by acute donor cell death as well as migration away from damaged areas. This is likely due to the fact that injected cells do not have the physical and biochemical cues for ordered engrafment. Here we evaluate 3 common biomatrices (Matrigel, Collagen I, Purmatrix) that has the potential of providing suitable scaffolds needed to enhance stem cell survival. The longitudinal fate of transplanted stem cells was monitored by reporter imaging techniques.
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