Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
M Kuro-o(National Center of Neurology and Psychiatry), Y Matsumura(The University of Texas Medical Branch at Galveston), H Aizawa, H Kawaguchi(The University of Texas Health Science Center at Houston), T Suga, T Utsugi, Y Ohyama, M Kurabayashi, T Kaname, E Kume, H Iwasaki, A Iida, T Shiraki-Iida, S Nishikawa, R Nagai, Y I Nabeshima
Cited by 66,557
Abstract
A new gene, termed klotho, has been identified that is involved in the suppression of several ageing phenotypes. A defect in klotho gene expression in the mouse results in a syndrome that resembles human ageing, including a short lifespan, infertility, arteriosclerosis, skin atrophy, osteoporosis and emphysema. The gene encodes a membrane protein that shares sequence similarity with the beta-glucosidase enzymes. The klotho gene product may function as part of a signalling pathway that regulates ageing in vivo and morbidity in age-related diseases.
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