Production of cytotoxic factor for oligodendrocytes by stimulated astrocytes.
Deanna S. Robbins(University of Maryland, Baltimore), Yasaman Shirazi(University of Maryland, Baltimore), B E Drysdale(University of Maryland, Baltimore), Andrew P. Lieberman(University of Maryland, Baltimore), H S Shin(University of Maryland, Baltimore), M L Shin(University of Maryland, Baltimore)
Cited by 429Open Access
Abstract
Stimulation of rat astrocytes in vitro by calcium ionophore A23187 and/or lipopolysaccharide results in the generation of a cytotoxic factor that is functionally similar to the previously described macrophage-derived cytotoxic factor, tumor necrosis factor. Like the macrophage product, the astrocyte cytotoxic factor kills murine L 929 cell targets. In addition, it kills rat oligodendrocytes, the myelin-producing cells of the central nervous system. Human recombinant tumor necrosis factor also has cytotoxic activity directed against rat oligodendrocytes.
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