Gold(iii) porphyrins as a new class of anticancer drugs: cytotoxicity, DNA binding and induction of apoptosis in human cervix epitheloid cancer cellsElectronic supplementary information (ESI) available: Further experimental and crystallographic details. See http://www.rsc.org/suppdata/cc/b3/b303294a/
Chi‐Ming Che(State Key Laboratory of Synthetic Chemistry), Raymond Wai‐Yin Sun(University of Hong Kong), Wing‐Yiu Yu(State Key Laboratory of Synthetic Chemistry), Chi-Bun Ko(University of Hong Kong), Nianyong Zhu(State Key Laboratory of Synthetic Chemistry), Hongzhe Sun(University of Hong Kong)
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Abstract
A series of gold(III) tetraarylporphyrins are stable in the presence of glutathione and exert much higher potency than cisplatin in killing human cancer cells, including the drug-resistant variants; the gold-induced cytotoxicity occurs through an apoptotic pathway according to laser confocal microscopy and flow cytometric studies.
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