Evaluation of Grid Pattern Photocoagulation for Macular Edema in Central Vein Occlusion

John G. Clarkson, Elaine L. Chuang, DONALD J. M. GASS, Maria Esperança de Marchiori Pedroso, T. Cubillas, E. S. Duria, Ditte J. Hess, Isabel Rams, Marguerite Ball, Alex Gutierrez, N. Muniz, June Thompson, M. Pall, Charles J. Pappas, Daniel Finkelstein(Johns Hopkins University), Arnall Patz(Johns Hopkins University), Dolores Rytel(Johns Hopkins University), Judy Belt(Johns Hopkins University), Dennis Cain(Johns Hopkins University), Terri Cain(Johns Hopkins University), David Emmert(Johns Hopkins University), Terry W. George(Johns Hopkins University), Mark Herring(Johns Hopkins University), Pete Sotirakos(Johns Hopkins University), David H. Orth, Timothy P. Flood, Kirk H. Packo, Toni Larsen, Nancy Pérez, Doug Bryant, Don Doherty, Jay B. Fitzgerald, Martha Gordon, Cynthia Holod, Kathy Kwiatkowski, Celeste MacLeod, Christopher N. Morrison, Charlotte Westcott, Michael L. Klein(Oregon Health & Science University), David J. Wilson(Oregon Health & Science University), Richard G. Weleber(Oregon Health & Science University), Susan K. Nolte(Oregon Health & Science University), Nancy Hurlburt(Oregon Health & Science University), Mark Evans(Oregon Health & Science University), Patrick Wallace(Oregon Health & Science University), Peter Steinkamp(Oregon Health & Science University), Debora Funkner(Oregon Health & Science University), Cathy Gordon(Oregon Health & Science University), Clement Trempe, Alex E. Jalkh, John J. Weiter, Sherry Anderson, Dennis M. Donovan, Tom O'Day, Gerald R. Friedman, Rodney Immerman, G. Coscas, G. Soubrane, Rose Marie Haran, Christophe Debibie, Jean Gizelsky, I. H. L. Wallow(University of Wisconsin–Madison), Guillermo de Venecia(University of Wisconsin–Madison), George H. Bresnick(University of Wisconsin–Madison), Sandra Larson(University of Wisconsin–Madison), Sandy Fuller(University of Wisconsin–Madison), Bob Harrison(University of Wisconsin–Madison), Gene Knutson(University of Wisconsin–Madison), Michael W. Neider(University of Wisconsin–Madison), Gregory M. Weber(University of Wisconsin–Madison), Ruth Huntley Bahr(University of Wisconsin–Madison), Bonnie Grosnick(University of Wisconsin–Madison), Robert Lazorik(University of Wisconsin–Madison), Helen Lyngaas(University of Wisconsin–Madison), Diane Quackenboss(University of Wisconsin–Madison), Guy Somers(University of Wisconsin–Madison), Froncie A. Gutman(Cleveland Clinic), Sanford Myers(Cleveland Clinic), Tina Kiss(Cleveland Clinic), D.A. Ross(Cleveland Clinic), Pamela Vargo(Cleveland Clinic), Janet Edgarton(Cleveland Clinic), Sue Hanson(Cleveland Clinic), Janet Nader(Cleveland Clinic), Nancy Tomsak(Cleveland Clinic), Lawrence J. Singerman, Hernando Zegarra, Susan Lichterman, Adrienne Fowler Kramer, Sheila Smith-Brewer, Pam Brown Rowe, Geraldine Daley, Anne Pinter, K. Coreno, Lori J. Cooper, Marty Delisio, Donna J. Cross, Wendy R. Lord, Argye Hillis, Mark W. Riggs, Cheryl KasbergPreece, M. Hasan Rajab, Krista Carlson Giniewicz, Kevin P. Gilmore, Carol Zimmerman, John G. Clarkson, Mary Lou Lewis(University of Miami), Elaine L. Chuang, Mason Wells(University of Miami), Julie Lord Forbes(University of Miami), Kathleen C. Fetzer(University of Miami), Heather McNish(University of Miami), George H. Bresnick(University of Wisconsin–Madison), Sandy Fuller(University of Wisconsin–Madison), Lissa McNulty(University of Wisconsin–Madison), Jim Baliker(University of Wisconsin–Madison), Linda Alanen(University of Wisconsin–Madison), Laura Gentry(University of Wisconsin–Madison), Richard L. Mowery(National Institutes of Health), Donald F. Everett(National Institutes of Health), John G. Clarkson, George H. Bresnick(University of Wisconsin–Madison), G. Coscas, Daniel Finkelstein(Johns Hopkins University), Froncie A. Gutman(Cleveland Clinic), Argye Hillis, Michael L. Klein(Oregon Health & Science University), Richard L. Mowery(National Institutes of Health), Donald F. Everett(National Institutes of Health), David H. Orth, Lawrence J. Singerman, Clement Trempe, Robert J. Hardy, Gary A. Abrams, Robert N. Frank, Maureen G. Maguire, Abner V. McCall, John G. Clarkson, Donald F. Everett(National Institutes of Health), Argye E. Hillis
Ophthalmology
October 1, 1995
10.1016/s0161-6420(95)30849-4
Cited by 509Open Access
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Abstract

PURPOSE: To evaluate the efficacy of macular grid photocoagulation in preserving or improving central visual acuity in eyes with macular edema due to central vein occlusion (CVO) and best-corrected visual acuity of 20/50 or poorer. METHODS: Patients with angiographically documented macular edema due to CVO were entered into a multicenter randomized controlled clinical trial supported by the National Eye Institute. Eligibility was determined based on both clinical examination findings and photographic documentation evaluated at a photograph reading center. Eyes were assigned randomly to macular grid photocoagulation (77 eyes) or no treatment (78 eyes). Patients were followed every 4 months for 3 years or until the end of the study. The outcome measure was visual acuity. RESULTS: The study population consisted of 155 eyes in 155 patients. There was no difference between treated and untreated eyes in visual acuity at any point during the follow-up period. Initial median visual acuity was 20/160 in treated eyes and 20/ 125 in control eyes. Final median visual acuity was 20/200 in treated eyes and 20/160 in control eyes. However, treatment clearly reduced angiographic evidence of macular edema. CONCLUSION: The results of this study do not support a recommendation for macular grid photocoagulation for the population meeting the Central Vein Occlusion Study macular edema group eligibility criteria.

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