AN EPIDEMIOLOGIC STUDY OF ALTERED CLINICAL REACTIVITY TO RESPIRATORY SYNCYTIAL (RS) VIRUS INFECTION IN CHILDREN PREVIOUSLY VACCINATED WITH AN INACTIVATED RS VIRUS VACCINE

Abstract

logic study of altered clinical reactivity to respiratory syncytial (RS) virus infection in children previously vaccinated with an inactivated RS virus vaccine. Amer. J. Epid., 1969,89: 405-421.—A formalin inactivated monkey kidney culture propagated 100-fold concentrated respiratory syncytial (RS) virus vaccine was administered intramuscularly to residents of Harrison and Arthur Cottages in Junior Village, a District of Columbia Welfare Institution for homeless but otherwise normal infants and children. No significant local or systemic vaccine reactions were observed. One to three doses of vaccine v/ere found to produce CF antibody titers of 1:8 to 1:256 in 27 (97%) of 28 seronegative (<1:4) residents; the vaccine also stimulated high levels of neutralizing antibody. A sharp outbreak of RS virus infection occurred approximately 9 months after the vaccine study was initiated; RS virus was recovered from 60 (41%) of 146 residents and serologic evidence of infection was detected in 37 (92%) of 40 seronegative individuals. Recovery of RS virus was found to be significantly associated not only with the onset of febrile illness but also with the onset of febrile pneumonia illness. The vaccine not only