Atom‐Economic Synthesis of Fully Substituted 2‐Aminopyrroles via Gold‐Catalyzed Formal [3+2] Cycloaddition between Ynamides and Isoxazoles

Xinyu Xiao(Xiamen University), Aihua Zhou(Xiamen University), Chao Shu(Xiamen University), Fei Pan(Xiamen University), Ting Li(Xiamen University), Long‐Wu Ye(Xiamen University)
Chemistry - An Asian Journal
June 20, 2015
Cited by 86

Abstract

A concise and flexible synthesis of fully substituted 2-aminopyrroles via gold-catalyzed formal [3+2] cycloaddition between ynamides and isoxazoles has been developed. Under mild reaction conditions, various 2-aminopyrrole derivatives were obtained in good to excellent yields, thus providing an efficient and atom-economic way for the construction of fully substituted 2-aminopyrroles.


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