<i>In vitro</i>production of IFN-γ correlates with CA repeat polymorphism in the human IFN-γ gene
Vera Pravica(University of Manchester), Argiris Asderakis, Chris Perrey(University of Manchester), Ali H. Hajeer(University of Manchester), P. J. Sinnott(University of Manchester), Ian V. Hutchinson(University of Manchester)
Cited by 455
Abstract
The DNA sequence of the human IFN-gamma gene shows the presence of a variable-length CA repeat in the first intron of the gene. We investigated the allele distribution of this microsatellite region in 164 unrelated healthy individuals, and the association with interferon-gamma (IFN-gamma) production. In vitro production of IFN-gamma showed a significant correlation with the presence of allele #2.
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