Evaluation of effectiveness and safety of hydroxyethyl starch (HES 130 kDa/0.4) in burn resuscitation

Abstract

Excessive fluid resuscitation of large burn injuries has been associated with adverse outcomes including worsening of burn oedema, conversion of superficial into deep burns, and compartment syndromes. So, there have been efforts recently to address these concerns, particularly with the use of physiologically balanced fluids. Starches, as effective plasma expanders, may limit resuscitation requirements and burn oedema. This study aims to evaluate clinical results of HES in early burn resuscitation of major burn-injured patients.