The Swedish CArdioPulmonary BioImage Study: objectives and design

Göran Bergström(Sahlgrenska University Hospital), G Berglund(Lund University), Anders Blomberg(Umeå University), John Brandberg(Sahlgrenska University Hospital), Gunnar Engström(Lund University), Jan Engvall(Linköping University), Mats Eriksson(Karolinska University Hospital), Ulf dé Fairé(Karolinska University Hospital), Agneta Flinck(Sahlgrenska University Hospital), Mats Hansson(Uppsala University), Bo Hedblad(Lund University), Ola Hjelmgren(Sahlgrenska University Hospital), Christer Janson(Uppsala University), Tomas Jernberg(Karolinska University Hospital), Åse A. Johnsson(Sahlgrenska University Hospital), L Johansson(Science for Life Laboratory), Lars Lind(Uppsala University), C.‐G. Löfdahl(Lund University), Olle Melander(Lund University), Carl Johan Östgren(Linköping University), Anders Persson(Linköping University), Margaretha Persson(Lund University), A. Sandström(Umeå University), Caroline Schmidt(University of Gothenburg), Stefan Söderberg(Umeå University), Johan Sundström(Uppsala University), Kjell Torén(University of Gothenburg), Anders Waldenström(Umeå University), Hans Wedel(Nordic School of Public Health), Jenny Vikgren(Sahlgrenska University Hospital), Björn Fagerberg(University of Gothenburg), Annika Rosengren(University of Gothenburg)
Journal of Internal Medicine
June 19, 2015
10.1111/joim.12384
Cited by 452Open Access
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Abstract

Cardiopulmonary diseases are major causes of death worldwide, but currently recommended strategies for diagnosis and prevention may be outdated because of recent changes in risk factor patterns. The Swedish CArdioPulmonarybioImage Study (SCAPIS) combines the use of new imaging technologies, advances in large-scale 'omics' and epidemiological analyses to extensively characterize a Swedish cohort of 30 000 men and women aged between 50 and 64 years. The information obtained will be used to improve risk prediction of cardiopulmonary diseases and optimize the ability to study disease mechanisms. A comprehensive pilot study in 1111 individuals, which was completed in 2012, demonstrated the feasibility and financial and ethical consequences of SCAPIS. Recruitment to the national, multicentre study has recently started.

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