Acute idiosyncratic reaction to hydrochlorothiazide ingestion.

Abstract

ADMINISTRATION OF THIAZIDE DIURETICS has been re- ported to produce various idiosyncratic reactions in- cluding skin rash,' urticaria, photosensitivity,' jaundice, necrotizing vasculitis' and bone marrow depression.- There have been six reported cases of idiosyncratic pulmonary edema reactions immediately following the ingestion of hydrochlorothiazide.8-12These previously reported cases have not been associated with bone mar- row depression.We report a case of hydrochlorothiazide-induced acute pulmonary edema and associated severe leukopenia and thrombocytopenia in a patient shortly after she ingested a single 50-mg tablet of hydrochlorothiazide.