The HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression

Abstract

The HL-60 cell line, derived from a single patient with acute promyelocytic leukemia, provides a unique in vitro model system for studying the cellular and molecular events involved in the proliferation and differentiation of normal and leukemic cells of the granulocyte/monocyte/macrophage lineage.