Tumor-infiltrating T lymphocytes improve clinical outcome of therapy-resistant neuroblastoma

Marco Mina(Fondazione Bruno Kessler), Renata Boldrini(Bambino Gesù Children's Hospital), Arianna Citti(Bambino Gesù Children's Hospital), Paolo Romania(Bambino Gesù Children's Hospital), Valerio D’Alicandro(Bambino Gesù Children's Hospital), Maretta De Ioris(Bambino Gesù Children's Hospital), Aurora Castellano(Bambino Gesù Children's Hospital), Cesare Furlanello(Fondazione Bruno Kessler), Franco Locatelli(University of Pavia), Doriana Fruci(Bambino Gesù Children's Hospital)
OncoImmunology
April 2, 2015
10.1080/2162402x.2015.1019981
Cited by 163Open Access
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Abstract

infiltrating T cells that associates with favorable clinical outcome in MYCN-amplified tumors, improving patient survival when combined with the v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (MYCN) status. These findings support the hypothesis that infiltrating T cells influence the behavior of neuroblastoma and might be of clinical importance for the treatment of patients.

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