Current knowledge on pathogenesis and immunodiagnosis of paracoccidioidomycosis.

Abstract

Host-parasite relationship and immunodiagnostic testing in paracoccidioidomycosis have been extensively investigated in recent years. We review the major advances in the understanding of pathogenesis of the disease with emphasis on the sequential steps in granuloma formation and the envolvement of immunological mechanisms in host defenses against the parasite. In addition, the several immunodiagnostic tests used for diagnosis and in the follow-up of patients are commented upon and critically analysed.