A DIFFERENCE IN MORTALITY RATE AND INCIDENCE OF KERNICTERUS AMONG PREMATURE INFANTS ALLOTTED TO TWO PROPHYLACTIC ANTIBACTERIAL REGIMENS
William A. Silverman(Columbia College), Dorothy H. Andersen(Columbia College), William A. Blanc(Columbia College), Douglas N. Crozier(Columbia College)
Cited by 549
Abstract
A controlled clinical trial was designed to test the relative effectiveness of two prophylactic antibacterial regimens administered to premature infants in the first 5 days of life. Infants who received penicillin/sulfisoxazole (diethanolamine) died at a significantly higher rate than those who received oxytetracycline. The incidence of kernicterus was significantly higher among infants who received penicillin/sulfisoxazole (diethanolamine).
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