Specificities of Prostaglandins B1, F1α, and F2α Antigen-Antibody Reactions

Abstract

Antibodiesto prostaglandins B1, FI,, and F2, recognize structural changes on the cyclopentane ring and, in part, the degree of saturation of the C5-C6 bond.Structural modifications in these two parts of the molecule are also known to be responsible for the varying physiological functions of the prostaglandins.The antiprostaglandins F1, and FZa distinguish the homologous prostaglandins from prostaglandins F1~ and Fzg in which the hydroxyl group on Cn is trans to the hydroxyl group on CL.The position of the double bond in the cyclopentane ring is also recognized by antibodies, suggesting that prostaglandins E and A in biological fluids may be estimated in terms of generated prostaglandin B by assay before and after base-catalyzed conversion of prostaglandin E, or prostaglandin A to prostaglandin B, or both.