The Genotype-Tissue Expression (GTEx) project
John T. Lonsdale, Jeffrey A. Thomas, Mike Salvatore, Rebecca Phillips, Edmund Lo, Saboor Shad, Richard Hasz(Gift of Life Michigan), Gary Walters(Lifenet Health), Fernando U. Garcia(Drexel University), Nancy Young(Einstein Medical Center Philadelphia), Barbara A. Foster(Roswell Park Comprehensive Cancer Center), Mike Moser(Roswell Park Comprehensive Cancer Center), Ellen Karasik(Roswell Park Comprehensive Cancer Center), Bryan M. Gillard(Roswell Park Comprehensive Cancer Center), Kimberley D. Ramsey(Roswell Park Comprehensive Cancer Center), Susan Sullivan, Jason Bridge, Harold I. Magazine(Phoenix (United States)), John Syron(Phoenix (United States)), Johnelle Fleming(Phoenix (United States)), Laura A. Siminoff(Virginia Commonwealth University), Heather M. Traino(Virginia Commonwealth University), Maghboeba Mosavel(Virginia Commonwealth University), Laura K. Barker(Virginia Commonwealth University), Scott D. Jewell(Van Andel Institute), Dan Rohrer(Van Andel Institute), Dan Maxim(Van Andel Institute), Dana Filkins(Van Andel Institute), P.R. Harbach(Van Andel Institute), Eddie Cortadillo(Van Andel Institute), Bree D. Berghuis(Van Andel Institute), Lisa Turner(Van Andel Institute), Eric A. Hudson(Van Andel Institute), Kristin Feenstra(Van Andel Institute), Leslie H. Sobin(Science Applications International Corporation (United States)), J Robb(Science Applications International Corporation (United States)), Phillip Branton, Greg E. Korzeniewski(Science Applications International Corporation (United States)), Charles Shive(Science Applications International Corporation (United States)), David E. Tabor(Science Applications International Corporation (United States)), Liqun Qi(Science Applications International Corporation (United States)), Kevin Groch(Science Applications International Corporation (United States)), Sreenath Nampally(Science Applications International Corporation (United States)), Steve Buia(Science Applications International Corporation (United States)), Angela Zimmerman(Science Applications International Corporation (United States)), Anna M. Smith(Science Applications International Corporation (United States)), Robin Burges(Science Applications International Corporation (United States)), Karna Robinson(Science Applications International Corporation (United States)), Kim Valentino(Science Applications International Corporation (United States)), Deborah Bradbury(Science Applications International Corporation (United States)), Mark Cosentino(Science Applications International Corporation (United States)), Norma Diaz-Mayoral(Science Applications International Corporation (United States)), Mary Kennedy(Science Applications International Corporation (United States)), Theresa Engel(Science Applications International Corporation (United States)), Penelope Williams(Science Applications International Corporation (United States)), Kenyon Erickson, Kristin G. Ardlie(Broad Institute), Wendy Winckler(Broad Institute), Gad Getz(Broad Institute), David S. DeLuca(Broad Institute), Daniel G. MacArthur(Broad Institute), Manolis Kellis(Broad Institute), Alexander Thomson(Broad Institute), Taylor Young(Broad Institute), Ellen Gelfand(Broad Institute), Molly Donovan(Broad Institute), Yan Meng(Broad Institute), George Grant(Broad Institute), Deborah C. Mash(University of Miami), Yvonne Marcus(University of Miami), Margaret J. Basile(University of Miami), Jun Liu(Harvard University), Jun Zhu(Icahn School of Medicine at Mount Sinai), Zhidong Tu(Icahn School of Medicine at Mount Sinai), Nancy J. Cox(University of Chicago), Dan L. Nicolae(University of Chicago), Eric R. Gamazon(University of Chicago), Hae Kyung Im(University of Chicago), Anuar Konkashbaev(University of Chicago), Jonathan K. Pritchard(Howard Hughes Medical Institute), Matthew Stevens(University of Chicago), Timothée Flutre(University of Chicago), Xiaoquan Wen(University of Chicago), Emmanouil T. Dermitzakis(University of Geneva), Tuuli Lappalainen(University of Geneva), Roderic Guigó(Centre for Genomic Regulation), Jean Monlong(Centre for Genomic Regulation), Michael Sammeth(Centre for Genomic Regulation), Daphne Koller(Palo Alto University), Alexis Battle(Palo Alto University), Sara Mostafavi(Palo Alto University), Mark I. McCarthy(University of Oxford), Manual Rivas(University of Oxford), Julian Maller(University of Oxford), Ivan Rusyn(University of North Carolina at Chapel Hill), Andrew B. Nobel(University of North Carolina at Chapel Hill), Fred A. Wright(University of North Carolina at Chapel Hill), Andrey A. Shabalin(University of North Carolina at Chapel Hill), Mike Feolo(National Institutes of Health), Nataliya Sharopova(National Institutes of Health), Anne Sturcke(National Institutes of Health), Justin Paschal(National Institutes of Health), James M. Anderson(National Institutes of Health), Elizabeth L. Wilder(National Institutes of Health), Leslie Derr(National Institutes of Health), Eric D. Green(National Human Genome Research Institute), Jeffery P. Struewing(National Human Genome Research Institute), Gary Temple(National Human Genome Research Institute), Simona Volpi(National Human Genome Research Institute), Joy T Boyer(National Human Genome Research Institute), Elizabeth J. Thomson(National Human Genome Research Institute), Mark S. Guyer(National Human Genome Research Institute), Cathy Ng(National Human Genome Research Institute), Assya Abdallah(National Human Genome Research Institute), Deborah Colantuoni(National Human Genome Research Institute), Thomas R. Insel(National Institute of Mental Health), Susan E. Koester(National Institute of Mental Health), A Roger Little(National Institute of Mental Health), Patrick K. Bender(National Institute of Mental Health), Thomas Lehner(National Institute of Mental Health), Yin Yao(National Institute of Mental Health), Carolyn C. Compton(National Cancer Institute), Jimmie B. Vaught(National Cancer Institute), Sherilyn J. Sawyer(National Cancer Institute), Nicole C. Lockhart(National Cancer Institute), Joanne P. Demchok(National Cancer Institute), Helen Moore(National Cancer Institute)
Cited by 265Open Access
Abstract
Genome-wide association studies have identified thousands of loci for common diseases, but, for the majority of these, the mechanisms underlying disease susceptibility remain unknown. Most associated variants are not correlated with protein-coding changes, suggesting that polymorphisms in regulatory regions probably contribute to many disease phenotypes. Here we describe the Genotype-Tissue Expression (GTEx) project, which will establish a resource database and associated tissue bank for the scientific community to study the relationship between genetic variation and gene expression in human tissues.
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