Oxidative stress in obstructive nephropathy
Amélie Dendooven(University Medical Center Utrecht), David Ishola(University of Groningen), Tri Q. Nguyen(Utrecht University), Dionne M. van der Giezen(Utrecht University), Robbert J. Kok(Utrecht University), Roel Goldschmeding(Utrecht University), Jaap A. Joles(University Medical Center Utrecht)
Cited by 120Open Access
Abstract
Unilateral ureteric obstruction (UUO) is one of the most commonly applied rodent models to study the pathophysiology of renal fibrosis. This model reflects important aspects of inflammation and fibrosis that are prominent in human kidney diseases. In this review, we present an overview of the factors contributing to the pathophysiology of UUO, highlighting the role of oxidative stress.
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