Copper-Mediated Trifluoromethylation Using Phenyl Trifluoromethyl Sulfoxide
Xinjin Li(Shanghai Institute of Organic Chemistry), Jingwei Zhao(Chinese Academy of Sciences), Liang Zhang(Shanghai Institute of Organic Chemistry), Mingyou Hu(Chinese Academy of Sciences), Limin Wang(East China University of Science and Technology), Jinbo Hu(Chinese Academy of Sciences)
Cited by 81
Abstract
A new method for the generation of trifluoromethylcopper ("CuCF3") species from readily available phenyl trifluoromethyl sulfoxide has been developed. The "CuCF3" reagent can be applied in efficient trifluoromethylations of aryl iodides and activated aryl bromides in the absence of additional ligands. Furthermore, the "CuCF3" species can also undergo oxidative cross-coupling with terminal alkynes and arylboronic acids.
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