The Genetic Basis of Human Cancer

Abstract

Part 1 Basic concepts in genetics: genetics, biochemistry and the molecular basis of variant human phenotypes the nature and mechanisms of human gene mutation the Human Genome Project genetic imprinting in cancer. Part 2 Controls on cell growth: control of the cell cycle apoptosis and cancer oncogenes tumour suppressor genes. Part 3A Inherited mutations - defects in DNA repair: xeroderma pigmentosa ataxia telangiectasia Bloom's syndrome Fanconi anaemia hereditary non-polyposis colorectal cancer Werner syndrome. Part 3B defects in growing controlling genes: retinoblastoma Li-Fraumenni syndrome Wilms tumour peripheral neurofibromatosis central neurofibromatosis renal carcinoma multiple endocrine neoplasia malignant melanoma breast cancer colorectal tumours. Part 4 Somatic mutations: chromosome translocations in leukemias and lymphomas chromosome rearrangements human in solid tumours gene amplification in human cancers - biological and clinical significance pancreatic cancer ovarian cancer endometrial cancer cervical cancer bladder cancer stomach cancer prostate cancer brain tumours lung cancer skin cancer hepatocellular carcinoma genetic testing for cancer.