Fusion of Cells by Flipped SNAREs
Chuan Hu(Memorial Sloan Kettering Cancer Center), Mahiuddin Ahmed(Memorial Sloan Kettering Cancer Center), Thomas J. Melia(Memorial Sloan Kettering Cancer Center), Thomas H. Söllner(Memorial Sloan Kettering Cancer Center), Thomas U. Mayer(Memorial Sloan Kettering Cancer Center), James E. Rothman(Memorial Sloan Kettering Cancer Center)
Cited by 247
Abstract
The SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) hypothesis suggests that pairs of proteins known as vesicle (v-) SNAREs and target membrane (t-) SNAREs interact specifically to control and mediate intracellular membrane fusion events. Here, cells expressing the interacting domains of v- and t-SNAREs on the cell surface were found to fuse spontaneously, demonstrating that SNAREs are sufficient to fuse biological membranes.
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