The Genetic Mapping of a Defective Lps Response Gene in C3H/HeJ Mice
James D. Watson(University of California, Irvine), Kathleen Kelly(University of California, Irvine), Michael Largen(University of California, Irvine), Benjamin A. Taylor(University of California, Irvine)
Cited by 280Open Access
Abstract
The expression of a defective LPS response gene Lps and the major urinary protein (Mup-1) are concordantly inherited in backcross (C3H/HeJ x C57BL/6J)F1 x C3H/HeJ mice, indicating genetic linkage of these loci. Mup-1 is known to be linked to the brown coat color locus on chromosome 4 in mice; thus Lps can now be assigned to chromosome 4. A value of 0.06 +/- 0.02 has been estimated for the recombination frequency between Mup-1 and Lps. We have used the polysyndactyly (Ps) mutation further to localize Lps on chromosome 4. Lps is located between the Mup-1 and Ps loci.
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