Studies on Scutellariae Radix. IV. Effect on lipid peroxidation in rat liver.

Abstract

It was found that the flavonoid components (wogonin, baicalein and baicalin) isolated from Scutellariae Radix (ogon in Japanese) inhibited lipid peroxidation in intact rat liver stimulated by the intraperitoneal administration of FeCl2-ascorbic acid-adenosine 5'-diphosphate (ADP) mixture. Various flavonoids of ogon also inhibited lipid peroxidation stimulated by FeCl2-ascorbic acid and nicotinamide adenine dinucleotide phosphate (NADPH)-ADP mixture in rat liver homogenate. Furthermore, it was found that baicalin, the major flavonoid component of ogon, reduced the increase of serum glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) levels in rats orally given an oxygen-bubbled rapeseed-corn-soybean oil mixture.