Stress, the Aging Brain, and the Mechanisms of Neuron Death

Abstract

Part 1 The glucocorticoid cascade hypothesis: the stress-response and the emergence of stress-related disease an introduction to the adrenocortical axis glucocorticoid concentrations in the aged rat - a problem of hypersecretion the problem of receptor loss the hippocampus as a mediator of glucocorticoid feedback regulation glucocorticoid neurotoxicity. Part 2 How does a neuron die?: glucocorticoids endanger hippocampal neurons a brief interlude - programmed cell death metabolic chaos 1 - the mediators of necrotic neuronal injury, metabolic chaos 2 - the role of energy failure in necrotic neuronal injury how do glucocorticoids endanger the hippocampal neuron?. Part 3 How depressing is all of this?: individual differences and adrenocortical function - why do some individuals secrete more glucocorticoids than others? interventions at the time of neurological insults is this relevant to the human?