The Primary Function of gp130 Signaling in Osteoblasts Is To Maintain Bone Formation and Strength, Rather Than Promote Osteoclast Formation

Rachelle W. Johnson(St Vincents Institute of Medical Research), Holly J. Brennan(The University of Melbourne), Christina Vrahnas(St Vincents Institute of Medical Research), Ingrid J. Poulton(St Vincents Institute of Medical Research), Narelle E. McGregor(St Vincents Institute of Medical Research), Therese Standal(Norwegian University of Science and Technology), Emma C. Walker(St Vincents Institute of Medical Research), Thuan-Tzen Koh(St Vincents Institute of Medical Research), Huynh Quoc Nguyen, Nicole C. Walsh(The University of Melbourne), Mark R. Forwood, T. John Martin(The University of Melbourne), Natalie A. Sims(The University of Melbourne)
Journal of Bone and Mineral Research
December 11, 2013
10.1002/jbmr.2159
Cited by 109Open Access
Full Text

Abstract

Interleukin-6 (IL-6) family cytokines act via gp130 in the osteoblast lineage to stimulate the formation of osteoclasts (bone resorbing cells) and the activity of osteoblasts (bone forming cells), and to inhibit expression of the osteocyte protein, sclerostin. We report here that a profound reduction in trabecular bone mass occurs both when gp130 is deleted in the entire osteoblast lineage (Osx1Cre gp130 f/f) and when this deletion is restricted to osteocytes (DMP1Cre gp130 f/f). This was caused not by an alteration in osteoclastogenesis, but by a low level of bone formation specific to the trabecular compartment. In contrast, cortical diameter increased to maintain ultimate bone strength, despite a reduction in collagen type 1 production. We conclude that osteocytic gp130 signaling is required for normal trabecular bone mass and proper cortical bone composition.

Related Papers

No related papers found

Powered by citation graph analysis