A new Saccharomyces cerevisiae mnn mutant N-linked oligosaccharide structure
Luis M. Hernández(University of California, Berkeley), L Ballou(University of California, Berkeley), Eugenio Alvarado(University of California, Berkeley), Beth L. Gillece-Castro(University of California, Berkeley), Alma L. Burlingame(University of California, Berkeley), Clinton E. Ballou(University of California, Berkeley)
Cited by 98Open Access
Abstract
We find that the N-linked Man8GlcNAc2- core oligosaccharide of Saccharomyces cerevisiae mnn mutant mannoproteins is enlarged by the addition of the outer chain to the alpha 1----3-linked mannose in the side chain that is attached to the beta 1----4-linked mannose rather than by addition to the terminal alpha 1----6-linked mannose. This conclusion is derived from structural studies on a phosphorylated oligosaccharide fraction and from mass spectral fragment analysis of neutral core oligosaccharides.
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