Exploiting Amino acid Structure to Learn About Membrane Transport

Abstract

This chapter contains sections titled: Introduction. The Necessity That Amino Acids be Transported Between Cells in the Higher Animal The Advantage of the Low Lipid Solubility of the Amino Acids Modifiability of the Amino Acid Structure. Dissociable Groups Recognition of Overlapping Systems for Neutral Amino Acid Transport Access to Some Amino Acids That Can Serve as Model Substrates Na+ as a Surrogate for the Side-chain Cationic Group Required by the Cationic Amino Acid System Paradoxical Transport of Diamino Acids by the Neutral Systems. Energization of Amino Acid Transport An Example of Efforts to Design a Model Substrate: System ASC Position of Na+ Binding at the Receptor Site for System ASC The Position Taken by Na+ at the System A Receptor Site. Amino Acid-Dependent Li+ Transport Role of Na+ in Transport of Dicarboxylic Amino Acids Why We Really Need a Model Substrate for System ASC. Incompletely Identified Transport Systems On the Relation Between Two Parallel Transport Systems Contrast Between Transport of Amino Acids Across the Blood-Brain Barrier and That Into Brain Slices Summary Comment