Lipopolysaccharide induces sickness behaviour in rats by a vagal mediated mechanism.
Rose-Marie Bluthé(Inserm), Verena Walter(Institut National de Recherche en Santé Publique), Patricia Parnet(Institut National de Recherche en Santé Publique), Sophie Layé(Institut National de Recherche en Santé Publique), Jacques Lestage(Institut National de Recherche en Santé Publique), D. Verrier(Institut National de Recherche en Santé Publique), S. Poole(Institut National de Recherche en Santé Publique), BRIDGET E. STENNING(Institut National de Recherche en Santé Publique), Keith W. Kelley(Institut National de Recherche en Santé Publique), Robert Dantzer(Institut National de Recherche en Santé Publique)
PubMed
June 1, 1994
Cited by 289
Abstract
To assess the possibility that lipopolysaccharide (LPS) induces sickness behaviour by activating primary afferent nerves, the effects of LPS (1.25 mg kg-1, intraperitoneally) were compared in vagotomized and sham-operated rats. Subdiaphragmatic vagotomy blocked the LPS-induced depression of social investigation but had no effect on LPS-induced increases in levels of IL-1 beta in plasma and peritoneal macrophages and on LPS-induced changes in dehydrogenase activity of peritoneal macrophages.
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