Leaderboards/Synthesis and Biological Evaluation

Synthesis and Biological Evaluation

Last updated July 15, 2026

Rising Stars

Fresh ink, massive impact

Researchers

1
Ilia Igashov
École Polytechnique Fédérale de Lausanne
2
Mohcine Missioui
Mohammed V University
3
Wen‐Tao Ouyang
University of South China
4
Anand Kumar Yadav
Tribhuvan University
5
Manankar Koley
Indian Institute of Science Education and Research Kolkata
6
Debora Chiodi
Takeda (United States)
7
Hazem Ali Mohamed
Zagazig University
8
Sean M. Burke
University of California San Diego
9
Nidhi Nehra
Indian Institute of Technology Bombay
10
Qiong-Hui Peng
University of South China

Papers

1
Equivariant 3D-conditional diffusion model for molecular linker design
Nature Machine Intelligence|2024
141 cit.
2
Anticancer mechanism of coumarin-based derivatives
European Journal of Medicinal Chemistry|2024
88 cit.
3
Publication in European Journal of Medicinal Chemistry (2024) [65 citations, W4393942216]
European Journal of Medicinal Chemistry|2024
65 cit.
4
Publication in Chinese Chemical Letters (2024) [61 citations, W4398200661]
Chinese Chemical Letters|2024
61 cit.
5
Structural mechanisms of α7 nicotinic receptor allosteric modulation and activation
Cell|2024
55 cit.
6
Synthesis, characterization, anticancer activity, molecular docking and DFT calculation of 3-acetylcoumarin thiosemicarbazones and Schiff’s bases
Results in Chemistry|2024
23 cit.
7
Publication in Chemistry - A European Journal (2024) [9 citations, W4395009033]
Chemistry - A European Journal|2024
9 cit.
8
Publication in Journal of Fluorescence (2024) [5 citations, W4400604209]
Journal of Fluorescence|2024
5 cit.
9
Novel hybrid quinoxaline-1,3,4-oxadiazole: Synthesis, crystal structure, computational and pharmacological studies
Journal of Molecular Structure|2025
2 cit.
10
Publication in Journal of Institute of Science and Technology (2024) [2 citations, W4412918344]
Journal of Institute of Science and Technology|2024
2 cit.

Emerging Leaders

Drafting the new consensus

Researchers

1
Wanmei Li
Hangzhou Normal University
2
Virender Singh
Central University of Punjab
3
Sabuj Kundu
Indian Institute of Technology Kanpur
4
Jeffrey K. Kerns
GlaxoSmithKline (United States)
5
Ori Green
Technion – Israel Institute of Technology
6
Bahaa G. M. Youssif
Assiut University
7
Jinwei Yuan
Wuhan University of Technology
8
Hazem Elkady
Al-Azhar University
9
Alaa Elwan
Al-Azhar University
10
Mohammed A. Dahab
Al-Azhar University

Papers

1
General and Modular Route to (Halo)alkyl BCP-Heteroaryls Enabled by α-Aminoalkyl Radical-Mediated Halogen-Atom Transfer
ACS Catalysis|2023
71 cit.
2
Well-Defined Phosphine-Free Manganese(II)-Complex-Catalyzed Synthesis of Quinolines, Pyrroles, and Pyridines
The Journal of Organic Chemistry|2022
63 cit.
3
Optimization and SAR investigation of novel 2,3-dihydropyrazino[1,2-a]indole-1,4-dione derivatives as EGFR and BRAFV600E dual inhibitors with potent antiproliferative and antioxidant activities
Bioorganic Chemistry|2022
59 cit.
4
Modified Benzoxazole-Based VEGFR-2 Inhibitors and Apoptosis Inducers: Design, Synthesis, and Anti-Proliferative Evaluation
Molecules|2022
59 cit.
5
New 1,3,4‐oxadiazoles linked with the 1,2,3‐triazole moiety as antiproliferative agents targeting the EGFR tyrosine kinase
Archiv der Pharmazie|2022
55 cit.
6
α-Amino Radical-Mediated Difunctionalization of Alkenes with Polyhaloalkanes and <i>N</i>-Heteroarenes
Organic Letters|2023
52 cit.
7
Energy-transfer photocatalysis for Minisci C–H (amino)alkylation of heteroarenes using oxime esters as dual-role reagents
Organic Chemistry Frontiers|2024
52 cit.
8
Screening a Panel of Topical Ophthalmic Medications against MMP-2 and MMP-9 to Investigate Their Potential in Keratoconus Management
Molecules|2022
50 cit.
9
Transition-metal-, oxidant- and additive-free multi-component synthesis of alkyl heteroaryl BCPs enabled by visible-light-induced phosphine-catalyzed halogen-atom transfer
Organic Chemistry Frontiers|2024
50 cit.
10
Benzoxazole derivatives as new VEGFR-2 inhibitors and apoptosis inducers: design, synthesis, <i>in silico</i> studies, and antiproliferative evaluation
Journal of Enzyme Inhibition and Medicinal Chemistry|2022
49 cit.

Current Senior Leaders

Wrote the book, still writing it

Researchers

1
Cheng‐He Zhou
Southwest University
2
William A. Denny
Maurice Wilkins Centre
3
Kenneth A. Jacobson
National Institutes of Health
4
Claudiu T. Supuran
University of Florence
5
Kuo‐Hsiung Lee
University of North Carolina at Chapel Hill
6
Dharmarajan Sriram
Birla Institute of Technology and Science, Pilani
7
Malcolm F. G. Stevens
Cardiff University
8
Anil K. Jaiswal
BioLegend (United States)
9
Erik De Clercq
Rega Institute for Medical Research
10
Berish Y. Rubin
Fordham University

Papers

1
Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity.
The Journal of Experimental Medicine|1983
2k cit.
2
Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds
Journal of Virological Methods|1988
1.6k cit.
3
Carbonic anhydrase inhibitors
Medicinal Research Reviews|2002
1.4k cit.
4
Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase <sub>1</sub>  gene
Proceedings of the National Academy of Sciences|1996
1k cit.
5
Phase transitions and phase separations in phospholipid membranes induced by changes in temperature, pH, and concentration of bivalent cations
Biochemistry|1975
765 cit.
6
A novel selective broad-spectrum anti-DNA virus agent
Nature|1986
764 cit.
7
Carbonic anhydrase inhibitors
Bioorganic & Medicinal Chemistry Letters|2010
612 cit.
8
Comparative Efficacy of Antiherpes Drugs against Different Strains of Herpes Simplex Virus
The Journal of Infectious Diseases|1980
604 cit.
9
Synthesis, antibacterial, antifungal and anti-HIV activities of Schiff and Mannich bases derived from isatin derivatives and N-[4-(4′-chlorophenyl)thiazol-2-yl] thiosemicarbazide
European Journal of Pharmaceutical Sciences|1999
581 cit.
10
Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes
Oncogene|1998
565 cit.

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