Leaderboards/Synthesis and bioactivity of alkaloids

Synthesis and bioactivity of alkaloids

Last updated July 15, 2026

Rising Stars

Fresh ink, massive impact

Researchers

1
Nisha
Unknown
2
Xiaofeng Min
Jiangmen Central Hospital
3
Wanyi Guo
Guangzhou University of Chinese Medicine
4
Pantha Prodip Ray
State University of Bangladesh
5
Akram Hegazy
Cairo University
6
Virginia J. Glick
Harvard University
7
Di Xiao
Hunan University of Traditional Chinese Medicine
8
Keisuke Kondo
Hokkaido University
9
Pramod Kumar
Institute of Himalayan Bioresource Technology
10
Aanchal Rathi
Jamia Millia Islamia

Papers

1
Investigation on the inhibition mechanism and binding behavior of cryptolepine to α-glucosidase and its hypoglycemic activity by multi-spectroscopic method
Journal of Luminescence|2024
70 cit.
2
Publication in Frontiers in Pharmacology (2024) [54 citations, W4392291911]
Frontiers in Pharmacology|2024
54 cit.
3
Molecular and quantum mechanical insights of conformational dynamics of Maltosyl-β-Cyclodextrin/Formononetin supramolecular complexes
Journal of Molecular Liquids|2024
41 cit.
4
Driving forces and large scale affinity calculations for piperine/γ-cyclodxetrin complexes: Mechanistic insights from umbrella sampling simulation and DFT calculations
Carbohydrate Polymers|2024
31 cit.
5
Exploring cyclodextrin-glabridin inclusion complexes: Insights into enhanced pharmaceutical formulations
Journal of Molecular Liquids|2024
26 cit.
6
Insights into inhibitory action and interaction of bisdemethoxycurcumin on tyrosinase: Spectroscopic and docking analysis
International Journal of Biological Macromolecules|2024
24 cit.
7
Refining the Trapping of Therapeutic Agent Silybin A in Functionalized β- and γ-Cyclodextrin Cavitands for Improved Supramolecular Complexation
Journal of Chemical Information and Modeling|2025
19 cit.
8
Anti-rheumatic colchicine phytochemical exhibits potent antiviral activities against avian and seasonal Influenza A viruses (IAVs) via targeting different stages of IAV replication cycle
BMC Complementary Medicine and Therapies|2024
8 cit.
9
Inhibition of Cyclin D1 by Novel Biguanide Derivative YB-004 Increases the Sensitivity of Bladder Cancer to Olaparib via Causing G0 / G1 Arrest
International Journal of Biological Sciences|2025
2 cit.
10
Publication in Food Chemistry (2026) [W7161836385]
Food Chemistry|2026
0 cit.

Emerging Leaders

Drafting the new consensus

Researchers

1
Virender Singh
Central University of Punjab
2
Yu‐Jing Lu
Dalian Polytechnic University
3
Xuetao Xu
Wuyi University
4
Adam Dahab Abdelhafiz
National Centre for Research
5
T.S. Xavier
University of Kerala
6
Araújo Rolim Larissa
Universidade Federal do Vale do São Francisco
7
Qingchun Zhao
Shenyang Pharmaceutical University
8
Najla AlMasoud
Princess Nourah bint Abdulrahman University
9
Sandeep Chandrashekharappa
National Institute of Pharmaceutical Education and Research
10
Zhan-Lin Li
Shenyang Pharmaceutical University

Papers

1
Synthesis and anti-α-glucosidase activity evaluation of betulinic acid derivatives
Arabian Journal of Chemistry|2023
96 cit.
2
Synthesis and biological evaluation of coumarin derivatives containing oxime ester as α-glucosidase inhibitors
Arabian Journal of Chemistry|2022
86 cit.
3
Investigation on the inhibition mechanism and binding behavior of cryptolepine to α-glucosidase and its hypoglycemic activity by multi-spectroscopic method
Journal of Luminescence|2024
70 cit.
4
Rational design of small-molecules to recognize G-quadruplexes of c-MYC promoter and telomere and the evaluation of their <i>in vivo</i> antitumor activity against breast cancer
Nucleic Acids Research|2022
65 cit.
5
Thiazolidine-2,4-dione derivatives as potential α-glucosidase inhibitors: Synthesis, inhibitory activity, binding interaction and hypoglycemic activity
Bioorganic Chemistry|2024
62 cit.
6
New β-carboline derivatives as potential α-glucosidase inhibitor: Synthesis and biological activity evaluation
Journal of Molecular Structure|2023
59 cit.
7
Hierarchical CaZrO3@rGO nanostructure as an electrode material for high-performance supercapacitor devices
Diamond and Related Materials|2024
52 cit.
8
Design, synthesis and biological evaluation of novel coumarin derivatives as multifunctional ligands for the treatment of Alzheimer's disease
European Journal of Medicinal Chemistry|2022
46 cit.
9
Synthesis, anti-α-glucosidase activity, inhibition interaction, and anti-diabetic activity of novel cryptolepine derivatives
Journal of Molecular Structure|2024
44 cit.
10
Design, synthesis, characterization, and anti-tubercular activity of novel ethyl-3-benzoyl-6, 8-difluoroindolizine-1-carboxylate analogues: Molecular target identification and molecular docking studies
Journal of Molecular Structure|2023
33 cit.

Current Senior Leaders

Wrote the book, still writing it

Researchers

1
Neil Osheroff
Vanderbilt University
2
Changhong Wang
Shanghai University of Traditional Chinese Medicine
3
Yves Pommier
National Cancer Institute
4
Rajesh Agarwal
University of Colorado Anschutz Medical Campus
5
J. A. Joule
University of Manchester
6
James M. Cook
University of Wisconsin–Milwaukee
7
Anlong Xu
Hong Kong Science and Technology Parks Corporation
8
Mark Cushman
University of Indianapolis
9
Rosa Erra‐Balsells
Universidad de Buenos Aires
10
Vladimı́r Křen
Czech Academy of Sciences

Papers

1
Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors
Cancer Research|2012
2.2k cit.
2
CellMiner: A Web-Based Suite of Genomic and Pharmacologic Tools to Explore Transcript and Drug Patterns in the NCI-60 Cell Line Set
Cancer Research|2012
931 cit.
3
Laying a trap to kill cancer cells: PARP inhibitors and their mechanisms of action
Science Translational Medicine|2016
759 cit.
4
Stereospecific PARP Trapping by BMN 673 and Comparison with Olaparib and Rucaparib
Molecular Cancer Therapeutics|2013
758 cit.
5
Induction of a Common Pathway of Apoptosis by Staurosporine
Experimental Cell Research|1994
508 cit.
6
Structure-activity study of the actions of camptothecin derivatives on mammalian topoisomerase I: evidence for a specific receptor site and a relation to antitumor activity.
PubMed|1989
450 cit.
7
Phosphorylation of Histone H2AX and Activation of Mre11, Rad50, and Nbs1 in Response to Replication-dependent DNA Double-strand Breaks Induced by Mammalian DNA Topoisomerase I Cleavage Complexes
Journal of Biological Chemistry|2003
446 cit.
8
Genomic analysis of the immune gene repertoire of amphioxus reveals extraordinary innate complexity and diversity
Genome Research|2008
393 cit.
9
Inhibition of human immunodeficiency virus type-1 integrase by curcumin
Biochemical Pharmacology|1995
376 cit.
10
Putative DNA/RNA helicase Schlafen-11 (SLFN11) sensitizes cancer cells to DNA-damaging agents
Proceedings of the National Academy of Sciences|2012
375 cit.

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