Leaderboards/Signaling Pathways in Disease

Signaling Pathways in Disease

Last updated July 15, 2026

Rising Stars

Fresh ink, massive impact

Researchers

1
Gustaf Ahdritz
Columbia University
2
Junedh Amrute
Amgen (United States)
3
Grace Q. Gong
London Cancer
4
Kazuhiro Koikawa
Beth Israel Deaconess Medical Center
5
Ke Wang
Yunnan University
6
Shannon Tansley
McGill University
7
Liguo Wang
University of Groningen
8
Jianjun Lv
Air Force Medical University
9
Jarrod Shilts
University of Cambridge
10
Yuxiong Lu
Sun Yat-sen University

Papers

1
OpenFold: retraining AlphaFold2 yields new insights into its learning mechanisms and capacity for generalization
Nature Methods|2024
289 cit.
2
Targeting immune–fibroblast cell communication in heart failure
Nature|2024
204 cit.
3
Targeting modulated vascular smooth muscle cells in atherosclerosis via FAP-directed immunotherapy
Science|2026
8 cit.
4
Precision Targeting of Mutant PI3Kα
Cancer Discovery|2024
6 cit.
5
ATP-competitive inhibitors of PI3K enzymes demonstrate an isoform selective dual action by controlling membrane binding
Biochemical Journal|2024
3 cit.
6
Abstract 4140393: Targeting Immune-Fibroblast Crosstalk in Myocardial Infarction and Cardiac Fibrosis
Circulation|2024
2 cit.
7
Abstract 151: Single Cell Transcriptional And Epigenetic Map Of Human Coronary Artery Disease In A Multi-ethnic Population
Arteriosclerosis Thrombosis and Vascular Biology|2024
0 cit.
8
How to build a human: Piecing together the body’s cellular puzzle
Science|2024
0 cit.
9
Abstract Or139: Single cell variant to enhancer to gene map for coronary artery disease
Arteriosclerosis Thrombosis and Vascular Biology|2025
0 cit.

Emerging Leaders

Drafting the new consensus

Researchers

1
Daniel A. Bachovchin
Memorial Sloan Kettering Cancer Center
2
Xin Jiang
Tsinghua University
3
Jianjun Yu
McGovern Institute for Brain Research
4
Stephen T. Yeung
Cornell University
5
Mohammed AlQuraishi
Harvard University
6
Raul Krauss
Eli Lilly (United States)
7
Meghan Kelly
University of California, San Francisco
8
Holly Ramage
Thomas Jefferson University
9
Catherine A. Makarewich
Cincinnati Children's Hospital Medical Center
10
Kyle J. Seamon
Revolution Medicines (United States)

Papers

1
Single-sequence protein structure prediction using a language model and deep learning
Nature Biotechnology|2022
425 cit.
2
OpenFold: retraining AlphaFold2 yields new insights into its learning mechanisms and capacity for generalization
Nature Methods|2024
289 cit.
3
CD169+ macrophage intrinsic IL-10 production regulates immune homeostasis during sepsis
Cell Reports|2023
65 cit.
4
Oxidized thioredoxin-1 restrains the NLRP1 inflammasome
Science Immunology|2022
50 cit.
5
The NLRP1 Inflammasome Induces Pyroptosis in Human Corneal Epithelial Cells
Investigative Ophthalmology & Visual Science|2022
48 cit.
6
The cardiac-enriched microprotein mitolamban regulates mitochondrial respiratory complex assembly and function in mice
Proceedings of the National Academy of Sciences|2022
40 cit.
7
The NLRP1 and CARD8 inflammasomes detect reductive stress
Cell Reports|2023
37 cit.
8
M24B aminopeptidase inhibitors selectively activate the CARD8 inflammasome
Nature Chemical Biology|2022
36 cit.
9
Protein folding stress potentiates NLRP1 and CARD8 inflammasome activation
Cell Reports|2023
36 cit.
10
High-throughput deep learning variant effect prediction with Sequence UNET
Genome biology|2023
33 cit.

Current Senior Leaders

Wrote the book, still writing it

Researchers

1
Eric N. Olson
Southwestern Medical Center
2
Jeffery D. Molkentin
Cincinnati Children's Hospital Medical Center
3
Stuart L. Schreiber
Broad Institute
4
Anjana Rao
La Jolla Institute for Immunology
5
Kun Ping Lu
University of North Carolina at Chapel Hill
6
Michael E. Greenberg
Harvard University
7
Gerald R. Crabtree
Stanford University
8
Andrew R. Marks
Columbia University
9
Jeffrey Milbrandt
James S. McDonnell Foundation
10
Zhi‐Nan Chen
National Medical Products Administration

Papers

1
Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor
Cell|1999
6.6k cit.
2
Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1
Science|2009
5.8k cit.
3
Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery
Cell|1997
5.7k cit.
4
Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis
Science|1995
5.3k cit.
5
Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
Cell|1991
4.1k cit.
6
Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase
Science|2004
3.2k cit.
7
Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene
Nature|1984
3.2k cit.
8
Printing Proteins as Microarrays for High-Throughput Function Determination
Science|2000
2.8k cit.
9
A Calcineurin-Dependent Transcriptional Pathway for Cardiac Hypertrophy
Cell|1998
2.6k cit.
10
Widespread transcription at neuronal activity-regulated enhancers
Nature|2010
2.5k cit.

Reagents for Signaling Pathways in Disease

Citation-validated products used in this field

🔥 Trending

Gaining adoption fast

⭐ Top Rated

Best all-around

Cell Signaling TechnologyEvidence 63

SPARC (D10F10) Rabbit Monoclonal Antibody

Cited in 10 papers
#8725$161,351
View Evidence →
Cell Signaling TechnologyEvidence 60

Western Blotting Application Solutions Kit

Cited in 10 papers
#12957$546
View Evidence →
Sigma-AldrichEvidence 63

Monoclonal Anti-alpha-Actinin (Sarcomeric) antibody produced in mouse

Cited in 9 papers
#A7811
View Evidence →

🌟 All-Time

Most validated

Cell Signaling TechnologyEvidence 67

Phospho-Elk-1 (Ser383) (2B1) Mouse Monoclonal Antibody

Cited in 13 papers
#9186$179,411
View Evidence →
Cell Signaling Technology

ADH1 Antibody

Cited in 11 papers
#5295$314
View Evidence →
Cell Signaling TechnologyEvidence 64

HDAC6 (D2E5) Rabbit Monoclonal Antibody

Cited in 10 papers
#7558$149,348
View Evidence →