Leaderboards/RNA and protein synthesis mechanisms

RNA and protein synthesis mechanisms

Last updated July 15, 2026

Rising Stars

Fresh ink, massive impact

Researchers

1
Benjamin Buchfink
Max Planck Institute for Biology
2
Tomáš Brůna
Lawrence Berkeley National Laboratory
3
Jeffrey A. Ruffolo
Joint BioEnergy Institute
4
Eric Nguyen
Microsoft (United States)
5
Max Schubach
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
6
Hugo Dalla-Torre
Institut Supérieur d'Électronique de Paris
7
Florian Tesson
Centre National de la Recherche Scientifique
8
Philipp Schake
Technische Universität Dresden
9
Pietro Boccaletto
International Institute of Molecular and Cell Biology
10
Nathan Cho
University of California, San Francisco

Papers

1
Sequence modeling and design from molecular to genome scale with Evo
Science|2024
427 cit.
2
Publication in Nucleic Acids Research (2024) [404 citations, W4390616142]
Nucleic Acids Research|2024
404 cit.
3
Nucleotide Transformer: building and evaluating robust foundation models for human genomics
Nature Methods|2024
380 cit.
4
Publication in Nucleic Acids Research (2025) [185 citations, W4410251219]
Nucleic Acids Research|2025
185 cit.
5
GeneMark-ETP significantly improves the accuracy of automatic annotation of large eukaryotic genomes
Genome Research|2024
134 cit.
6
Designing proteins with language models
Nature Biotechnology|2024
97 cit.
7
A Comprehensive Resource for Exploring Antiphage Defense: DefenseFinder Webservice,Wiki and Databases
Peer Community Journal|2024
82 cit.
8
Design of highly functional genome editors by modelling CRISPR–Cas sequences
Nature|2025
72 cit.
9
Exploring the diversity of anti-defense systems across prokaryotes, phages and mobile genetic elements
Nucleic Acids Research|2024
56 cit.
10
Navigating Eukaryotic Genome Annotation Pipelines: A Route Map to Using BRAKER, Galba, and TSEBRA
Methods in molecular biology|2025
9 cit.

Emerging Leaders

Drafting the new consensus

Researchers

1
Alexander D. MacKerell
University of Maryland, Baltimore
2
Brian Hie
Palo Alto Institute
3
Alexander Rives
New York Consortium in Evolutionary Primatology
4
Halil Akin
Lokman Hekim Üniversitesi
5
Roshan Rao
Chan Zuckerberg Biohub San Francisco
6
Hajk‐Georg Drost
Max Planck Institute for Biology
7
Brejnev Muhire
Van Andel Institute
8
Rui Xia
Yangtze University
9
Omar O. Abudayyeh
Brigham and Women's Hospital
10
Kyle Kai‐How Farh
Illumina (United States)

Papers

1
Evolutionary-scale prediction of atomic-level protein structure with a language model
Science|2023
4.9k cit.
2
TBtools-II: A “one for all, all for one” bioinformatics platform for biological big-data mining
Molecular Plant|2023
3.5k cit.
3
Simulating 500 million years of evolution with a language model
Science|2025
603 cit.
4
Efficient evolution of human antibodies from general protein language models
Nature Biotechnology|2023
450 cit.
5
Sequence modeling and design from molecular to genome scale with Evo
Science|2024
427 cit.
6
The landscape of tolerated genetic variation in humans and primates
Science|2023
177 cit.
7
Evolutionary velocity with protein language models predicts evolutionary dynamics of diverse proteins
Cell Systems|2022
159 cit.
8
Rapid in silico directed evolution by a protein language model with EVOLVEpro
Science|2024
156 cit.
9
A painless way to customize Circos plot: From data preparation to visualization using TBtools
iMeta|2022
136 cit.
10
Identification of constrained sequence elements across 239 primate genomes
Nature|2023
113 cit.

Current Senior Leaders

Wrote the book, still writing it

Researchers

1
Steven L. Salzberg
Johns Hopkins University
2
Toby J. Gibson
European Molecular Biology Laboratory
3
Daron M. Standley
The University of Osaka
4
David Baker
Howard Hughes Medical Institute
5
Feng Zhang
Broad Institute
6
Jonathan S. Weissman
Howard Hughes Medical Institute
7
T Gingeras
Cold Spring Harbor Laboratory
8
George M. Church
Harvard University Press
9
Janet M. Thornton
European Bioinformatics Institute
10
David R. Liu
New York Hospital Queens

Papers

1
CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
Nucleic Acids Research|1994
64.9k cit.
2
Fast gapped-read alignment with Bowtie 2
Nature Methods|2012
61.1k cit.
3
STAR: ultrafast universal RNA-seq aligner
Bioinformatics|2012
56.2k cit.
4
MAFFT Multiple Sequence Alignment Software Version 7: Improvements in Performance and Usability
Molecular Biology and Evolution|2013
48.3k cit.
5
HISAT: a fast spliced aligner with low memory requirements
Nature Methods|2015
26.1k cit.
6
PROCHECK: a program to check the stereochemical quality of protein structures
Journal of Applied Crystallography|1993
24.6k cit.
7
Ultrafast and memory-efficient alignment of short DNA sequences to the human genome
Genome biology|2009
23k cit.
8
FLASH: fast length adjustment of short reads to improve genome assemblies
Bioinformatics|2011
15.7k cit.
9
Multiplex Genome Engineering Using CRISPR/Cas Systems
Science|2013
15.7k cit.
10
Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype
Nature Biotechnology|2019
15.7k cit.

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