Leaderboards/Protein Tyrosine Phosphatases

Protein Tyrosine Phosphatases

Last updated July 15, 2026

Rising Stars

Fresh ink, massive impact

Papers

Co-targeting SOS1 enhances the antitumor effects of KRASG12C inhibitors by addressing intrinsic and acquired resistance

Nature Cancer|2024

47 cit.

Structural basis of Cdk7 activation by dual T-loop phosphorylation

Nature Communications|2024

20 cit.

An expanded trove of fragment-bound structures for the allosteric enzyme PTP1B from computational reanalysis of large-scale crystallographic data

Structure|2024

14 cit.

Sequence – dynamics – function relationships in protein tyrosine phosphatases

QRB Discovery|2024

13 cit.

Publication in Journal of Medicinal Chemistry (2024) [11 citations, W4401049069]

Journal of Medicinal Chemistry|2024

11 cit.

Publication in European Journal of Medicinal Chemistry (2024) [5 citations, W4404489312]

European Journal of Medicinal Chemistry|2024

5 cit.

Publication in Cancer Research (2024) [1 citation, W4393100867]

Cancer Research|2024

1 cit.

Publication in Cell Reports (2024) [1 citation, W4396514452]

Cell Reports|2024

1 cit.

Publication in Journal of Medicinal Chemistry (2026) [1 citation, W7161155077]

Journal of Medicinal Chemistry|2026

1 cit.

Publication in Journal of Medicinal Chemistry (2026) [W7164073923]

Journal of Medicinal Chemistry|2026

0 cit.

Emerging Leaders

Drafting the new consensus

Researchers

Nadia J. Kershaw

The University of Melbourne

Yasushi Kondo

Paul Scherrer Institute

Kwan Ho Tang

AstraZeneca (Netherlands)

Huai‐Xiang Hao

Novartis (Switzerland)

Weiwei Yang

Center for Excellence in Molecular Cell Science

Wei Li

Zhejiang Normal University

Poulikos I. Poulikakos

Icahn School of Medicine at Mount Sinai

Maria Francesca Baietti

KU Leuven

Elizabeth R. Sharlow

Kerry Group (Ireland)

Jerome M. Fox

University of Colorado Boulder

Papers

MAPK signalling-induced phosphorylation and subcellular translocation of PDHE1α promotes tumour immune evasion

Nature Metabolism|2022

49 cit.

Pyruvate Facilitates FACT‐Mediated <i>γ</i>H2AX Loading to Chromatin and Promotes the Radiation Resistance of Glioblastoma

Advanced Science|2022

44 cit.

Fructose-1,6-bisphosphatase 1 dephosphorylates IκBα and suppresses colorectal tumorigenesis

Cell Research|2023

40 cit.

IGFBP1 Sustains Cell Survival during Spatially‐Confined Migration and Promotes Tumor Metastasis

Advanced Science|2023

27 cit.

Effects of dapagliflozin monotherapy and combined aerobic exercise on skeletal muscle mitochondrial quality control and insulin resistance in type 2 diabetes mellitus rats

Biomedicine & Pharmacotherapy|2023

19 cit.

Exercise attenuates high-fat diet-induced PVAT dysfunction through improved inflammatory response and BMP4-regulated adipose tissue browning

Frontiers in Nutrition|2024

17 cit.

Ketosynthase mutants enable short-chain fatty acid biosynthesis in E. coli

Metabolic Engineering|2023

12 cit.

Compensative role of autochthonous lactic acid bacteria in physical properties and taste profiles of dry sausage with partial substitution of NaCl by KCl

LWT|2024

12 cit.

Disruption of Ovarian Cancer STAT3 and p38 Signaling with a Small-Molecule Inhibitor of PTP4A3 Phosphatase

Journal of Pharmacology and Experimental Therapeutics|2023

11 cit.

GrapevineXL reliably predicts multi-annual dynamics of vine water status, berry growth, and sugar accumulation in vineyards

Horticulture Research|2023

11 cit.

Current Senior Leaders

Wrote the book, still writing it

Papers

Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

Cell|1999

6.6k cit.

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

Cell|1997

5.7k cit.

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

Science|1995

5.3k cit.

<i>PTEN</i> , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer

Science|1997

4.8k cit.

Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase

Science|2004

3.2k cit.

Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene

Nature|1984

3.2k cit.

The Tumor Suppressor, PTEN/MMAC1, Dephosphorylates the Lipid Second Messenger, Phosphatidylinositol 3,4,5-Trisphosphate

Journal of Biological Chemistry|1998

3.1k cit.

Widespread transcription at neuronal activity-regulated enhancers

Nature|2010

2.5k cit.

Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt

Science|1997

2.5k cit.

Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

Nature Genetics|1997

2.1k cit.

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