Leaderboards/Prion Diseases and Protein Misfolding

Prion Diseases and Protein Misfolding

Last updated July 15, 2026

Rising Stars

Fresh ink, massive impact

Papers

Engineered virus-like particles for transient delivery of prime editor ribonucleoprotein complexes in vivo

Nature Biotechnology|2024

236 cit.

Brainwide silencing of prion protein by AAV-mediated delivery of an engineered compact epigenetic editor

Science|2024

103 cit.

Performance of a seed amplification assay for misfolded alpha-synuclein in cerebrospinal fluid and brain tissue in relation to Lewy body disease stage and pathology burden

Acta Neuropathologica|2024

94 cit.

Publication in Nature Nanotechnology (2024) [73 citations, W4399437416]

Nature Nanotechnology|2024

73 cit.

Publication in Nature Medicine (2025) [39 citations, W4406374689]

Nature Medicine|2025

39 cit.

Clinical value of novel blood‐based tau biomarkers in Creutzfeldt–Jakob disease

Alzheimer s & Dementia|2024

19 cit.

Distinct tau filament folds in human MAPT mutants P301L and P301T

Nature Structural & Molecular Biology|2025

14 cit.

Diagnostic and Prognostic Value of Plasma GFAP in Sporadic Creutzfeldt–Jakob Disease in the Clinical Setting of Rapidly Progressive Dementia

International Journal of Molecular Sciences|2024

8 cit.

Clinical, neuropathological, and molecular characteristics of rapidly progressive dementia with Lewy bodies: a distinct clinicopathological entity?

Alzheimer s Research & Therapy|2024

7 cit.

Cryo-EM structure of the vault from human brain reveals symmetry mismatch at its caps

Structure|2025

7 cit.

Emerging Leaders

Drafting the new consensus

Papers

Direct prediction of intrinsically disordered protein conformational properties from sequence

Nature Methods|2024

226 cit.

TDP-43 forms amyloid filaments with a distinct fold in type A FTLD-TDP

Nature|2023

162 cit.

Heteromeric amyloid filaments of ANXA11 and TDP-43 in FTLD-TDP type C

Nature|2024

78 cit.

Sequence-based prediction of intermolecular interactions driven by disordered regions

Science|2025

77 cit.

Tau filaments are tethered within brain extracellular vesicles in Alzheimer’s disease

Nature Neuroscience|2024

75 cit.

An Introduction to the Stickers-and-Spacers Framework as Applied to Biomolecular Condensates

Methods in molecular biology|2022

70 cit.

Integrated transcriptome landscape of ALS identifies genome instability linked to TDP-43 pathology

Nature Communications|2023

61 cit.

TAF15 amyloid filaments in frontotemporal lobar degeneration

Nature|2023

52 cit.

The Analytical Flory Random Coil Is a Simple-to-Use Reference Model for Unfolded and Disordered Proteins

The Journal of Physical Chemistry B|2023

41 cit.

SOURSOP: A Python Package for the Analysis of Simulations of Intrinsically Disordered Proteins

Journal of Chemical Theory and Computation|2023

41 cit.

Current Senior Leaders

Wrote the book, still writing it

Researchers

Stanley B. Prusiner

University of California, San Francisco

Dennis J. Selkoe

Brigham and Women's Hospital

Susan Lindquist

Howard Hughes Medical Institute

John Collinge

National Health Service

Adriano Aguzzi

University Hospital of Zurich

Christopher M. Dobson

University of Cambridge

Byron Caughey

Government of the United States of America

Michel Goedert

MRC Laboratory of Molecular Biology

David Eisenberg

UCLA Health

Charles Glabe

University of California, Irvine

Papers

Novel Proteinaceous Infectious Particles Cause Scrapie

Science|1982

5.1k cit.

Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo

Nature|2002

4.3k cit.

Common Structure of Soluble Amyloid Oligomers Implies Common Mechanism of Pathogenesis

Science|2003

4.1k cit.

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

Nature Medicine|2008

3.7k cit.

Assessment of protein models with three-dimensional profiles

Nature|1992

3.5k cit.

α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson’s disease and dementia with Lewy bodies

Proceedings of the National Academy of Sciences|1998

3.2k cit.

A Method to Identify Protein Sequences That Fold into a Known Three-Dimensional Structure

Science|1991

2.9k cit.

Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

Neuron|1989

2.5k cit.

Hsp90 as a capacitor for morphological evolution

Nature|1998

2.3k cit.

Analysis of membrane and surface protein sequences with the hydrophobic moment plot

Journal of Molecular Biology|1984

2.3k cit.

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