Leaderboards/Phosphodiesterase function and regulation

Phosphodiesterase function and regulation

Last updated July 15, 2026

Rising Stars

Fresh ink, massive impact

Researchers

1
Zablon Kerima Ondara
Unknown
2
Selma E. Anton
Max Delbrück Center
3
Jenny C. Filor
Institut de Biologie Moléculaire et Cellulaire
4
Sulaiman K. Marafie
Dasman Diabetes Institute
5
Tianfei Fan
Sichuan University
6
Liang Wang
Chinese Academy of Sciences
7
Edda S. F. Matthees
Institute of Molecular Biotechnology
8
Wagner S. Brum
Universidade Federal do Rio Grande do Sul
9
Crystian I Massengill
Beth Israel Deaconess Medical Center
10
Moritz Lehners
Universität Hamburg

Papers

1
mTOR: Its Critical Role in Metabolic Diseases, Cancer, and the Aging Process
International Journal of Molecular Sciences|2024
85 cit.
2
PDE4 inhibitors: potential protective effects in inflammation and vascular diseases
Frontiers in Pharmacology|2024
47 cit.
3
A blood-based biomarker workflow for optimal tau-PET referral in memory clinic settings
Nature Communications|2024
30 cit.
4
GRK specificity and Gβγ dependency determines the potential of a GPCR for arrestin-biased agonism
Communications Biology|2024
22 cit.
5
Helix-bundle and C-terminal GPCR domains differentially influence GRK-specific functions and β-arrestin-mediated regulation
Nature Communications|2025
3 cit.
6
Targeting mTOR Kinase with Natural Compounds: Potent ATP-Competitive Inhibition Through Enhanced Binding Mechanisms
Pharmaceuticals|2024
2 cit.
7
Reversible tau hyperphosphorylation in hibernation: a blood biomarker and brain tissue study
Acta Neuropathologica|2025
2 cit.
8
Publication in Signal Transduction and Targeted Therapy (2024) [W4400666512]
Signal Transduction and Targeted Therapy|2024
0 cit.
9
Optimizing tau‐PET referrals in memory clinics through a blood biomarker workflow
Alzheimer s & Dementia|2024
0 cit.
10
Publication in Journal of Pharmacology and Experimental Therapeutics (2025) [W4408936140]
Journal of Pharmacology and Experimental Therapeutics|2025
0 cit.

Emerging Leaders

Drafting the new consensus

Researchers

1
Sai‐Sai Xie
First Affiliated Hospital of Xi'an Jiaotong University
2
Yaseen A. M. M. Elshaier
University of Sadat City
3
Marie Anna Nandeuil
Chiesi (France)
4
Canmao Wang
Southern University of Science and Technology
5
Tim Vanmierlo
Maastricht University
6
Patrizia Giannoni
Centre National de la Recherche Scientifique
7
Lingyin Li
Stanford University
8
Lily I. Jiang
AMS (Singapore)
9
Nesrine S. El Sayed
Cairo University
10
Ju-Wan Kim
Chonnam National University

Papers

1
ENPP1’s regulation of extracellular cGAMP is a ubiquitous mechanism of attenuating STING signaling
Proceedings of the National Academy of Sciences|2022
102 cit.
2
Selective PDE4 subtype inhibition provides new opportunities to intervene in neuroinflammatory versus myelin damaging hallmarks of multiple sclerosis
Brain Behavior and Immunity|2022
67 cit.
3
ENPP1 is an innate immune checkpoint of the anticancer cGAMP–STING pathway in breast cancer
Proceedings of the National Academy of Sciences|2023
66 cit.
4
PI3K/AKT signaling activation by roflumilast ameliorates rotenone-induced Parkinson’s disease in rats
Inflammopharmacology|2023
46 cit.
5
NLRP3 inflammasome inhibition and M1-to-M2 microglial polarization shifting via scoparone-inhibited TLR4 axis in ovariectomy/D-galactose Alzheimer's disease rat model
International Immunopharmacology|2023
43 cit.
6
Design, synthesis and chemoinformatic studies of new thiazolopyrimidine derivatives as potent anticancer agents via phosphodiesterase-5 inhibition and apoptotic inducing activity
Journal of Molecular Structure|2022
39 cit.
7
Identification of the extracellular membrane protein ENPP3 as a major cGAMP hydrolase and innate immune checkpoint
Cell Reports|2024
36 cit.
8
From methylation to myelination: epigenomic and transcriptomic profiling of chronic inactive demyelinated multiple sclerosis lesions
Acta Neuropathologica|2023
26 cit.
9
Chemistry of 2-vinylindoles: synthesis and applications
New Journal of Chemistry|2022
25 cit.
10
Design, Synthesis and In Vitro Evaluation of Spirooxindole-Based Phenylsulfonyl Moiety as a Candidate Anti-SAR-CoV-2 and MERS-CoV-2 with the Implementation of Combination Studies
International Journal of Molecular Sciences|2022
23 cit.

Current Senior Leaders

Wrote the book, still writing it

Researchers

1
Miles D. Houslay
University of Glasgow
2
Marco Conti
Stanford Medicine
3
Jackie D. Corbin
National Hospital
4
Akira Sawa
Johns Hopkins University
5
Rodolphe Fischmeister
Inserm
6
David A. Kass
Johns Hopkins University
7
David J. Porteous
Western General Hospital
8
Benjamin Weiss
Occidental College
9
Manuela Zaccolo
University of Oxford
10
Guo‐li Ming
University of Pennsylvania

Papers

1
Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure
Cell|2016
2.2k cit.
2
Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth
Cell stem cell|2016
1.3k cit.
3
Estimation of Central Aortic Pressure Waveform by Mathematical Transformation of Radial Tonometry Pressure
Circulation|1997
1.3k cit.
4
S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding
Nature Cell Biology|2005
1.1k cit.
5
EGF-Like Growth Factors As Mediators of LH Action in the Ovulatory Follicle
Science|2004
1.1k cit.
6
Improved Left Ventricular Mechanics From Acute VDD Pacing in Patients With Dilated Cardiomyopathy and Ventricular Conduction Delay
Circulation|1999
974 cit.
7
Combined Ventricular Systolic and Arterial Stiffening in Patients With Heart Failure and Preserved Ejection Fraction
Circulation|2003
928 cit.
8
Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy
Nature Medicine|2005
898 cit.
9
Discrete Microdomains with High Concentration of cAMP in Stimulated Rat Neonatal Cardiac Myocytes
Science|2002
843 cit.
10
Effective arterial elastance as index of arterial vascular load in humans.
Circulation|1992
828 cit.

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