Leaderboards/Pharmacogenetics and Drug Metabolism

Pharmacogenetics and Drug Metabolism

Last updated July 15, 2026

Rising Stars

Fresh ink, massive impact

Researchers

Guo‐Li Xiong

King University

Marlena Stielow

Nicolaus Copernicus University

Simon D Harding

Neurosciences Institute

V. S. Kulkarni

MNR Dental College and Hospital

Ana M B Amorim

Polytechnic Institute of Coimbra

Panxia Zhao

Chinese Academy of Sciences

Salman Raza

Unknown

Chang‐Keun Cho

American Association of Colleges of Pharmacy

Yingbo Huang

Kunming University of Science and Technology

Sebastjan Kralj

University of Maribor

Papers

Advancing Drug Safety in Drug Development: Bridging Computational Predictions for Enhanced Toxicity Prediction

Chemical Research in Toxicology|2024

112 cit.

Crucial gating residues govern the enhancement of peroxygenase activity in an engineered cytochrome P450 <i>O</i>-demethylase

Chemical Science|2024

24 cit.

The IUPHAR/BPS Guide to PHARMACOLOGY in 2026

Nucleic Acids Research|2025

19 cit.

Publication in Archives of Pharmacal Research (2024) [13 citations, W4395449657]

Archives of Pharmacal Research|2024

13 cit.

Publication in Neuro-Oncology (2024) [9 citations, W4403157483]

Neuro-Oncology|2024

9 cit.

Artificial intelligence in rare diseases: toward clinical impact

Trends in Pharmacological Sciences|2025

7 cit.

Publication in Pharmaceutics (2024) [3 citations, W4391219491]

Pharmaceutics|2024

3 cit.

Publication in Archives of Pharmacal Research (2024) [1 citation, W4405837664]

Archives of Pharmacal Research|2024

1 cit.

Publication in Cancer Research (2024) [W4392370897]

Cancer Research|2024

0 cit.

Emerging Leaders

Drafting the new consensus

Papers

A 12-gene pharmacogenetic panel to prevent adverse drug reactions: an open-label, multicentre, controlled, cluster-randomised crossover implementation study

The Lancet|2023

514 cit.

DGIdb 5.0: rebuilding the drug–gene interaction database for precision medicine and drug discovery platforms

Nucleic Acids Research|2023

445 cit.

How Do Preorganized Electric Fields Function in Catalytic Cycles? The Case of the Enzyme Tyrosine Hydroxylase

Journal of the American Chemical Society|2022

81 cit.

Application of a gut–liver-on-a-chip device and mechanistic modelling to the quantitative <i>in vitro</i> pharmacokinetic study of mycophenolate mofetil

Lab on a Chip|2022

67 cit.

Exploration and application of a liver-on-a-chip device in combination with modelling and simulation for quantitative drug metabolism studies

Lab on a Chip|2022

64 cit.

How Do Metalloproteins Tame the Fenton Reaction and Utilize •OH Radicals in Constructive Manners?

Accounts of Chemical Research|2022

63 cit.

How the Conformational Movement of the Substrate Drives the Regioselective C–N Bond Formation in P450 TleB: Insights from Molecular Dynamics Simulations and Quantum Mechanical/Molecular Mechanical Calculations

Journal of the American Chemical Society|2023

52 cit.

Collaborative deep learning improves disease-related circRNA prediction based on multi-source functional information

Briefings in Bioinformatics|2023

48 cit.

Predicting drug–target binding affinity with cross-scale graph contrastive learning

Briefings in Bioinformatics|2023

32 cit.

[4Fe–4S]-Mediated Proton-Coupled Electron Transfer Enables the Efficient Degradation of Chloroalkenes by Reductive Dehalogenases

ACS Catalysis|2023

31 cit.

Current Senior Leaders

Wrote the book, still writing it

Papers

SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules

Scientific Reports|2017

17.1k cit.

The Carbon Monoxide-binding Pigment of Liver Microsomes

Journal of Biological Chemistry|1964

11.8k cit.

SwissTargetPrediction: updated data and new features for efficient prediction of protein targets of small molecules

Nucleic Acids Research|2019

4.2k cit.

An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)

Journal of Biological Chemistry|1995

3.6k cit.

The Carbon Monoxide-binding Pigment of Liver Microsomes

Journal of Biological Chemistry|1964

3.5k cit.

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

Journal of Pharmacology and Experimental Therapeutics|1994

2.8k cit.

A BOILED‐Egg To Predict Gastrointestinal Absorption and Brain Penetration of Small Molecules

ChemMedChem|2016

2.4k cit.

SwissParam: A fast force field generation tool for small organic molecules

Journal of Computational Chemistry|2011

2.3k cit.

Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ

Proceedings of the National Academy of Sciences|1997

2.2k cit.

A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation

Cell|1995

2k cit.

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