Leaderboards/Pediatric Hepatobiliary Diseases and Treatments

Pediatric Hepatobiliary Diseases and Treatments

Last updated July 15, 2026

Rising Stars

Fresh ink, massive impact

Researchers

1
Bipin Rimal
Pennsylvania State University
2
Iiris Nyholm
University of Helsinki
3
Baihua Wu
Chinese Academy of Sciences
4
Zhuolong Tu
Wenzhou Medical University
5
Kapil Goutam
Centre National de la Recherche Scientifique
6
Ciliang Jin
Wenzhou Medical University
7
Shuhang Liang
University of Science and Technology of China
8
Hannah R. Hrncir
Emory University
9
Qigu Yao
National Center for Infectious Diseases
10
Zinan Zhao
Tongji University

Papers

1
Bile salt hydrolase catalyses formation of amine-conjugated bile acids
Nature|2024
205 cit.
2
Publication in Nature Genetics (2024) [54 citations, W4394832287]
Nature Genetics|2024
54 cit.
3
Publication in Nature Communications (2024) [43 citations, W4403173764]
Nature Communications|2024
43 cit.
4
Publication in Journal of Controlled Release (2024) [20 citations, W4401476078]
Journal of Controlled Release|2024
20 cit.
5
Publication in Journal of Hepatology (2025) [14 citations, W4406940363]
Journal of Hepatology|2025
14 cit.
6
Cholelithiasis, Cholecystitis, and Choledocholithiasis
New England Journal of Medicine|2025
0 cit.
7
Walled-Off Pancreatic Necrosis
New England Journal of Medicine|2026
0 cit.
8
Publication in Portal hypertension & cirrhosis (2026) [W7160320302]
Portal hypertension & cirrhosis|2026
0 cit.

Emerging Leaders

Drafting the new consensus

Researchers

1
A. Sloan Devlin
Harvard University
2
Jun R. Huh
Harvard University
3
Weihui Yan
XinHua Hospital
4
T. T. Young
Princess of Wales Hospital
5
Casey M. Theriot
North Carolina State University
6
Cen Xie
Nanjing University of Chinese Medicine
7
Shijun He
Shanghai University of Traditional Chinese Medicine
8
Morten Ejby
Technical University of Denmark
9
Jason M. Ridlon
University of Illinois Urbana-Champaign
10
Peter Szitányi
Charles University

Papers

1
Human gut bacteria produce ΤΗ17-modulating bile acid metabolites
Nature|2022
552 cit.
2
Hepatic cytochrome P450 8B1 and cholic acid potentiate intestinal epithelial injury in colitis by suppressing intestinal stem cell renewal
Cell stem cell|2022
192 cit.
3
Bile salt hydrolases shape the bile acid landscape and restrict Clostridioides difficile growth in the murine gut
Nature Microbiology|2023
169 cit.
4
A biosynthetic pathway for the selective sulfonation of steroidal metabolites by human gut bacteria
Nature Microbiology|2022
88 cit.
5
Gut bacteria convert glucocorticoids into progestins in the presence of hydrogen gas
Cell|2024
88 cit.
6
Formation of secondary allo-bile acids by novel enzymes from gut Firmicutes
Gut Microbes|2022
60 cit.
7
Limosilactobacillus reuteri and caffeoylquinic acid synergistically promote adipose browning and ameliorate obesity-associated disorders
Microbiome|2022
55 cit.
8
Caffeic acid phenethyl ester suppresses intestinal FXR signaling and ameliorates nonalcoholic fatty liver disease by inhibiting bacterial bile salt hydrolase activity
Acta Pharmacologica Sinica|2022
54 cit.
9
Inhibition of microbial deconjugation of micellar bile acids protects against intestinal permeability and liver injury
Science Advances|2022
45 cit.
10
Isolation and analyses of lamina propria lymphocytes from mouse intestines
STAR Protocols|2022
41 cit.

Current Senior Leaders

Wrote the book, still writing it

Researchers

1
Nancy B. Spinner
Children's Hospital of Philadelphia
2
Gregory J. Gores
Mayo Clinic in Arizona
3
Steven A. Kliewer
Southwestern Medical Center
4
Nicholas F. LaRusso
Mayo Clinic
5
Michael M. Gottesman
National Cancer Institute
6
James L. Boyer
Celldex Therapeutics (United States)
7
Yuichi Sugiyama
ShanghaiTech University
8
Yasuni Nakanuma
Fukui-ken Saiseikai Hospital
9
Frank J. Gonzalez
National Cancer Institute
10
Ulrich Brinkmann
Roche (Switzerland)

Papers

1
An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)
Journal of Biological Chemistry|1995
3.6k cit.
2
A "Silent" Polymorphism in the <i>MDR</i> 1 Gene Changes Substrate Specificity
Science|2006
2.5k cit.
3
Functional polymorphisms of the human multidrug-resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity <i>in</i> <i>vivo</i>
Proceedings of the National Academy of Sciences|2000
2.4k cit.
4
Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ
Proceedings of the National Academy of Sciences|1997
2.2k cit.
5
A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation
Cell|1995
2k cit.
6
A Regulatory Cascade of the Nuclear Receptors FXR, SHP-1, and LRH-1 Represses Bile Acid Biosynthesis
Molecular Cell|2000
1.9k cit.
7
Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis
Cell Metabolism|2005
1.8k cit.
8
Targeted Disruption of the Nuclear Receptor FXR/BAR Impairs Bile Acid and Lipid Homeostasis
Cell|2000
1.8k cit.
9
Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors
Nature|1992
1.7k cit.
10
Targeted Disruption of the α Isoform of the Peroxisome Proliferator-Activated Receptor Gene in Mice Results in Abolishment of the Pleiotropic Effects of Peroxisome Proliferators
Molecular and Cellular Biology|1995
1.6k cit.

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