Leaderboards/Mitochondrial Function and Pathology

Mitochondrial Function and Pathology

Last updated July 15, 2026

Rising Stars

Fresh ink, massive impact

Researchers

1
Hongxu Xian
National University of Singapore
2
Yun-Zi Mao
Obstetrics and Gynecology Hospital of Fudan University
3
Keun Woo Ryu
Memorial Sloan Kettering Cancer Center
4
Yuanjiu Lei
Yale University
5
Theophania Ashleigh
Cornell University
6
Ruei-Zeng Lin
Boston Children's Hospital
7
Madelyn Klemmensen
University of Iowa
8
Alva M. Casey
University of Cambridge
9
Laura F. DiGiovanni
University of Toronto
10
Joonho Suh
Seoul National University Dental Hospital

Papers

1
Hypoxia induces mitochondrial protein lactylation to limit oxidative phosphorylation
Cell Research|2024
292 cit.
2
Cellular ATP demand creates metabolically distinct subpopulations of mitochondria
Nature|2024
245 cit.
3
Mitochondrial transfer mediates endothelial cell engraftment through mitophagy
Nature|2024
216 cit.
4
Publication in Nature Metabolism (2025) [99 citations, W4407752013]
Nature Metabolism|2025
99 cit.
5
Publication in Science (2025) [94 citations, W4412165109]
Science|2025
94 cit.
6
Mitochondria as secretory organelles and therapeutic cargos
Experimental & Molecular Medicine|2024
53 cit.
7
Mitochondrial DNA oxidation propagates autoimmunity by enabling plasmacytoid dendritic cells to induce TFH differentiation
Nature Immunology|2025
14 cit.
8
AMPKα2 signals amino acid insufficiency to inhibit protein synthesis
Cell Metabolism|2025
7 cit.
9
Circulating oxidized mitochondrial DNA drives autoimmunity
The Journal of Immunology|2024
1 cit.
10
Publication in Trends in Endocrinology and Metabolism (2025) [1 citation, W4414107595]
Trends in Endocrinology and Metabolism|2025
1 cit.

Emerging Leaders

Drafting the new consensus

Researchers

1
Francesca Cavalcanti
National Academies of Sciences, Engineering, and Medicine
2
Katrien De Bock
ETH Zurich
3
James A. Letts
University of California, Davis
4
Antentor Hinton
Vanderbilt University
5
Gerta Hoxhaj
Children's Medical Center
6
Edward J. Wild
Huntington's Disease Association
7
Hui Jiang
Beijing University of Technology
8
Kutti R. Vinothkumar
National Centre for Biological Sciences
9
Valentin Cracan
Scripps Research Institute
10
Adam L. Hughes
University of Utah

Papers

1
Mitochondrial Structure and Function in Human Heart Failure
Circulation Research|2024
175 cit.
2
De novo and salvage purine synthesis pathways across tissues and tumors
Cell|2024
165 cit.
3
Mitochondria in disease: changes in shapes and dynamics
Trends in Biochemical Sciences|2024
146 cit.
4
MitoTracker: A useful tool in need of better alternatives
European Journal of Cell Biology|2023
132 cit.
5
Mitochondrial cristae architecture protects against mtDNA release and inflammation
Cell Reports|2022
129 cit.
6
A mitochondrial SCF‐FBXL4 ubiquitin E3 ligase complex degrades BNIP3 and NIX to restrain mitophagy and prevent mitochondrial disease
The EMBO Journal|2023
110 cit.
7
Structures of <i>Tetrahymena</i> ’s respiratory chain reveal the diversity of eukaryotic core metabolism
Science|2022
100 cit.
8
Purine nucleotide depletion prompts cell migration by stimulating the serine synthesis pathway
Nature Communications|2022
85 cit.
9
A mitophagy sensor PPTC7 controls BNIP3 and NIX degradation to regulate mitochondrial mass
Molecular Cell|2023
80 cit.
10
MME+ fibro-adipogenic progenitors are the dominant adipogenic population during fatty infiltration in human skeletal muscle
Communications Biology|2023
73 cit.

Current Senior Leaders

Wrote the book, still writing it

Researchers

1
Xiaodong Wang
Shanghai Children's Medical Center
2
Douglas C. Wallace
Children's Hospital of Philadelphia
3
Nikolaus Pfanner
University of Freiburg
4
Richard J. Youle
National Institutes of Health
5
Martin D. Brand
Buck Institute for Research on Aging
6
Guido Kroemer
Institut Universitaire de France
7
Vamsi K. Mootha
Center for Human Genetics
8
Luca Scorrano
University of Padua
9
John E. Walker
San Francisco Department of Public Health
10
Michael P. Murphy
University of Cambridge

Papers

1
PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
Nature Genetics|2003
10.6k cit.
2
Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade
Cell|1997
7.3k cit.
3
Autophagy in the Pathogenesis of Disease
Cell|2008
7k cit.
4
Distantly related sequences in the alpha‐ and beta‐subunits of ATP synthase, myosin, kinases and other ATP‐requiring enzymes and a common nucleotide binding fold.
The EMBO Journal|1982
5.3k cit.
5
Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c
Cell|1996
5.2k cit.
6
Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked
Science|1997
4.9k cit.
7
Molecular characterization of mitochondrial apoptosis-inducing factor
Nature|1999
4k cit.
8
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
The Journal of Cell Biology|2008
4k cit.
9
Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors
Cell|1998
3.6k cit.
10
Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition
Cell|2000
3.5k cit.

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