Leaderboards/Microbial Natural Products and Biosynthesis

Microbial Natural Products and Biosynthesis

Last updated July 15, 2026

Rising Stars

Fresh ink, massive impact

Researchers

1
Barbara R. Terlouw
Wageningen University & Research
2
Xujun Zhang
Zhejiang University
3
Benjamin I. Tingle
University of California, San Francisco
4
Ana Hernández-Plaza
Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria
5
Simon D Harding
Neurosciences Institute
6
Conor J. McClune
Howard Hughes Medical Institute
7
Jeffrey A. van Santen
Simon Fraser University
8
Venkata Chandrasekhar Nainala
Friedrich Schiller University Jena
9
Gabriel Studer
SIB Swiss Institute of Bioinformatics
10
Ruiyun Huo
Chinese Academy of Sciences

Papers

1
COCONUT 2.0: a comprehensive overhaul and curation of the collection of open natural products database
Nucleic Acids Research|2024
122 cit.
2
Advancing Ligand Docking through Deep Learning: Challenges and Prospects in Virtual Screening
Accounts of Chemical Research|2024
72 cit.
3
HawkDock version 2: an updated web server to predict and analyze the structures of protein–protein complexes
Nucleic Acids Research|2025
29 cit.
4
The IUPHAR/BPS Guide to PHARMACOLOGY in 2026
Nucleic Acids Research|2025
19 cit.
5
RAIChU: automating the visualisation of natural product biosynthesis
Journal of Cheminformatics|2024
4 cit.
6
eggNOG v7: phylogeny-based orthology predictions and functional annotations
Nucleic Acids Research|2025
3 cit.
7
A fully automated benchmarking suite to compare macromolecular complexes
Nature Methods|2025
3 cit.
8
Publication (2024) [W4405271398]
Unknown Journal|2024
0 cit.
9
Publication in Journal of Computational Methods in Sciences and Engineering (2025) [W4413121470]
Journal of Computational Methods in Sciences and Engineering|2025
0 cit.
10
Publication in Phytochemistry Letters (2025) [W4415610738]
Phytochemistry Letters|2025
0 cit.

Emerging Leaders

Drafting the new consensus

Researchers

1
Hucheng Zhu
Huazhong University of Science and Technology
2
Fei Cao
Ministry of Education of the People's Republic of China
3
Annie E. Tsong
Amyris (United States)
4
Hans Renata
Rice University
5
Yudai Matsuda
The University of Tokyo
6
Ling‐Hong Meng
Institute of Oceanology
7
Xiaoying Bian
Unilever (China)
8
Yi Zou
The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture
9
Mark R. Wildung
Washington State University
10
Eduard J. Kerkhoven
Chalmers University of Technology

Papers

1
Recent Progress and Developments in Chemoenzymatic and Biocatalytic Dynamic Kinetic Resolution
Organic Process Research & Development|2022
68 cit.
2
Remote B-Ring Oxidation of Sclareol with an Engineered P450 Facilitates Divergent Access to Complex Terpenoids
Journal of the American Chemical Society|2022
55 cit.
3
Yeast9: a consensus genome-scale metabolic model for S. cerevisiae curated by the community
Molecular Systems Biology|2024
50 cit.
4
Selenium supplementation enhanced the expression of selenoproteins in hippocampus and played a neuroprotective role in LPS-induced neuroinflammation
International Journal of Biological Macromolecules|2023
49 cit.
5
Overview of Amino Acid Modifications by Iron- and α-Ketoglutarate-Dependent Enzymes
ACS Catalysis|2023
49 cit.
6
Concise Chemoenzymatic Synthesis of Gedunin
Journal of the American Chemical Society|2022
48 cit.
7
Oxalierpenes A and B, Unusual Indole-Diterpenoid Derivatives with Antiviral Activity from a Marine-Derived Strain of the Fungus <i>Penicillium oxalicum</i>
Journal of Natural Products|2022
36 cit.
8
Berberine bridge enzyme-like oxidase-catalysed double bond isomerization acts as the pathway switch in cytochalasin synthesis
Nature Communications|2022
34 cit.
9
HGTphyloDetect: facilitating the identification and phylogenetic analysis of horizontal gene transfer
Briefings in Bioinformatics|2023
31 cit.
10
Modular chemoenzymatic synthesis of ten fusicoccane diterpenoids
Nature Chemistry|2024
31 cit.

Current Senior Leaders

Wrote the book, still writing it

Researchers

1
K. Barry Sharpless
Scripps Research Institute
2
Marnix H. Medema
Wageningen University & Research
3
Christopher T. Walsh
Met Office
4
Tilmann Weber
Novo Nordisk Foundation
5
Jay D. Keasling
QB3
6
Chaitan Khosla
Stanford University
7
William Fenical
Scripps Institution of Oceanography
8
Rolf Müller
Virginia Tech
9
Christian Hertweck
Czech Academy of Sciences, Institute of Microbiology
10
Peter Proksch
Nnamdi Azikiwe University

Papers

1
Click Chemistry: Diverse Chemical Function from a Few Good Reactions
Angewandte Chemie International Edition|2001
13k cit.
2
A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed Regioselective “Ligation” of Azides and Terminal Alkynes
Angewandte Chemie International Edition|2002
11.5k cit.
3
Click Chemistry: Diverse Chemical Function from a Few Good Reactions
Angewandte Chemie International Edition|2001
9.3k cit.
4
antiSMASH 5.0: updates to the secondary metabolite genome mining pipeline
Nucleic Acids Research|2019
3.1k cit.
5
Production of the antimalarial drug precursor artemisinic acid in engineered yeast
Nature|2006
2.8k cit.
6
antiSMASH 6.0: improving cluster detection and comparison capabilities
Nucleic Acids Research|2021
2.7k cit.
7
The first practical method for asymmetric epoxidation
Journal of the American Chemical Society|1980
2.6k cit.
8
Publication in Angewandte Chemie (2002) [2318 citations, W4231340065]
Angewandte Chemie|2002
2.3k cit.
9
antiSMASH 7.0: new and improved predictions for detection, regulation, chemical structures and visualisation
Nucleic Acids Research|2023
2.2k cit.
10
antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences
Nucleic Acids Research|2011
2k cit.

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