Leaderboards/Microbial Metabolic Engineering and Bioproduction

Microbial Metabolic Engineering and Bioproduction

Last updated July 15, 2026

Rising Stars

Fresh ink, massive impact

Researchers

1
Tianzhi Wu
University of California, San Francisco
2
Sarah Lewis
Microsoft Research (United Kingdom)
3
Fungmin Liew
AZ Technology (United States)
4
Barbara R. Terlouw
Wageningen University & Research
5
Alexander Kroll
Steinbeis Foundation
6
Grant M. Landwehr
Northwestern University
7
Yunzhuo Zhou
Baker Heart and Diabetes Institute
8
Mahesh M. Shanbhag
KLE Technological University
9
Vivek Narisetty
Cranfield University
10
Paige K. Arnold
Memorial Sloan Kettering Cancer Center

Papers

1
Scalable emulation of protein equilibrium ensembles with generative deep learning
Science|2025
221 cit.
2
Publication in Nature Communications (2025) [100 citations, W4406614983]
Nature Communications|2025
100 cit.
3
Publication in Nucleic Acids Research (2024) [53 citations, W4398782969]
Nucleic Acids Research|2024
53 cit.
4
DLKcat cannot predict meaningful <i>k</i>cat values for mutants and unfamiliar enzymes
Biology Methods and Protocols|2024
30 cit.
5
A multimodal Transformer Network for protein-small molecule interactions enhances predictions of kinase inhibition and enzyme-substrate relationships
PLoS Computational Biology|2024
29 cit.
6
Detection of Perfluorooctanoic and Perfluorodecanoic Acids on a Graphene-Based Electrochemical Sensor Aided by Computational Simulations
Langmuir|2024
24 cit.
7
SPOT: A machine learning model that predicts specific substrates for transport proteins
PLoS Biology|2024
21 cit.
8
Exploring the role of saline water splitting in sustainable energy solutions and hydrogen economy
Applied Energy|2025
20 cit.
9
Publication in Surfaces and Interfaces (2024) [17 citations, W4397023765]
Surfaces and Interfaces|2024
17 cit.
10
Publication in ACS Applied Nano Materials (2024) [13 citations, W4394603854]
ACS Applied Nano Materials|2024
13 cit.

Emerging Leaders

Drafting the new consensus

Researchers

1
Kanae Morishima
Kyoto Bunkyo University
2
Mari Ishiguro-Watanabe
Tokyo University of Science
3
Benjamin VanderSluis
University of Minnesota
4
Elizabeth N. Koch
University of Minnesota
5
Rodrigo Ledesma‐Amaro
Imperial College London
6
Douglas E. V. Pires
Fundação Oswaldo Cruz
7
Eduard J. Kerkhoven
Chalmers University of Technology
8
Λεωνίδας Μάτσακας
Luleå University of Technology
9
Xin Zhu
Karlsruhe Institute of Technology
10
Arivalagan Pugazhendhi
Asia University

Papers

1
KEGG for taxonomy-based analysis of pathways and genomes
Nucleic Acids Research|2022
6.5k cit.
2
KEGG: biological systems database as a model of the real world
Nucleic Acids Research|2024
2.1k cit.
3
Microplastics in the environment: A critical overview on its fate, toxicity, implications, management, and bioremediation strategies
Journal of Environmental Management|2023
283 cit.
4
New insights into microbial electrolysis cells (MEC) and microbial fuel cells (MFC) for simultaneous wastewater treatment and green fuel (hydrogen) generation
Fuel|2023
170 cit.
5
Futuristic food fortification with a balanced ratio of dietary ω-3/ω-6 omega fatty acids for the prevention of lifestyle diseases
Trends in Food Science & Technology|2022
139 cit.
6
Bioprocessing of volatile fatty acids by oleaginous freshwater microalgae and their potential for biofuel and protein production
Chemical Engineering Journal|2022
84 cit.
7
Influence of biomass and nanoadditives in dark fermentation for enriched bio-hydrogen production: A detailed mechanistic review on pathway and commercialization challenges
Fuel|2022
77 cit.
8
Inducible expression of large gRNA arrays for multiplexed CRISPRai applications
Nature Communications|2022
69 cit.
9
Green synthesis of copper oxide nanoparticles using Abutilon indicum leaves extract and their evaluation of antibacterial, anticancer in human A549 lung and MDA-MB-231 breast cancer cells
Food and Chemical Toxicology|2022
62 cit.
10
Production of waste tyre pyrolysis oil as the replacement for fossil fuel for diesel engines with constant hydrogen injection via air intake manifold
Fuel|2023
57 cit.

Current Senior Leaders

Wrote the book, still writing it

Researchers

1
Trey Ideker
Moores Cancer Center
2
Bernhard Ø. Palsson
University of California San Diego
3
Gavin Sherlock
Stanford University
4
Minoru Kanehisa
Kyoto University
5
Kevin Cowtan
University of York
6
Jens Nielsen
BioInnovation Institute
7
Janet M. Thornton
European Bioinformatics Institute
8
Peer Bork
Max Delbrück Center
9
Christian von Mering
SIB Swiss Institute of Bioinformatics
10
Torsten Schwede
SIB Swiss Institute of Bioinformatics

Papers

1
Cytoscape: A Software Environment for Integrated Models of Biomolecular Interaction Networks
Genome Research|2003
54.3k cit.
2
Gene Ontology: tool for the unification of biology
Nature Genetics|2000
44.6k cit.
3
KEGG: Kyoto Encyclopedia of Genes and Genomes
Nucleic Acids Research|2000
39.2k cit.
4
KEGG: Kyoto Encyclopedia of Genes and Genomes
Nucleic Acids Research|1999
32.4k cit.
5
<i>Coot</i>: model-building tools for molecular graphics
Acta Crystallographica Section D Biological Crystallography|2004
31.4k cit.
6
Features and development of <i>Coot</i>
Acta Crystallographica Section D Biological Crystallography|2010
29.6k cit.
7
PROCHECK: a program to check the stereochemical quality of protein structures
Journal of Applied Crystallography|1993
24.6k cit.
8
STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets
Nucleic Acids Research|2018
19.2k cit.
9
SWISS-MODEL: homology modelling of protein structures and complexes
Nucleic Acids Research|2018
13.6k cit.
10
Interactive Tree Of Life (iTOL) v5: an online tool for phylogenetic tree display and annotation
Nucleic Acids Research|2021
11.7k cit.

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