Leaderboards/interferon and immune responses

interferon and immune responses

Last updated July 15, 2026

Rising Stars

Fresh ink, massive impact

Researchers

1
Stella Victorelli
Mayo Clinic
2
Hongxu Xian
National University of Singapore
3
Juan Ignacio Jiménez‐Loygorri
National Research Council
4
Marc Elosua-Bayés
Centro Nacional de Análisis Genómico
5
Yuanjiu Lei
Yale University
6
Ping Lai
Institute of Oncology Research
7
Joe C. Udeochu
Cornell University
8
Jun Li
Second Affiliated Hospital of Zhejiang University
9
Christy Hong
University Medical Center Groningen
10
Richard de Reuver
Ghent University

Papers

1
Mitophagy curtails cytosolic mtDNA-dependent activation of cGAS/STING inflammation during aging
Nature Communications|2024
289 cit.
2
Publication in Immunity (2025) [101 citations, W4409254393]
Immunity|2025
101 cit.
3
Urolithin A promotes p62-dependent lysophagy to prevent acute retinal neurodegeneration
Molecular Neurodegeneration|2024
24 cit.
4
Aging STINGs: mitophagy at the crossroads of neuroinflammation
Autophagy|2024
21 cit.
5
Mitochondrial DNA oxidation propagates autoimmunity by enabling plasmacytoid dendritic cells to induce TFH differentiation
Nature Immunology|2025
14 cit.
6
Mitochondrial RNA cytosolic leakage drives the SASP
Nature Communications|2025
12 cit.
7
Recycling the recyclers: lysophagy emerges as a new pharmacological target for retinal degeneration
Autophagy|2024
7 cit.
8
Fast and quantitative mitophagy assessment by flow cytometry using the mito-QC reporter
Frontiers in Cell and Developmental Biology|2024
7 cit.
9
Defective chaperone-mediated autophagy in the retinal pigment epithelium of age-related macular degeneration patients
EMBO Molecular Medicine|2025
6 cit.
10
Circulating oxidized mitochondrial DNA drives autoimmunity
The Journal of Immunology|2024
1 cit.

Emerging Leaders

Drafting the new consensus

Researchers

1
Andrea Ablasser
École Polytechnique Fédérale de Lausanne
2
Nader Yatim
Institut Pasteur
3
Philip J. Kranzusch
Harvard University
4
Nicholas C. Wu
University of Illinois Urbana-Champaign
5
Yun Zhu
Chinese Academy of Sciences
6
Pinglong Xu
Zhejiang University-University of Edinburgh Institute
7
Konstantin M. J. Sparrer
German Center for Neurodegenerative Diseases
8
Lingyin Li
Stanford University
9
Yunkai Yu
Zhejiang University of Science and Technology
10
Zhibo Liu
Beijing National Laboratory for Molecular Sciences

Papers

1
cGAS–STING drives ageing-related inflammation and neurodegeneration
Nature|2023
925 cit.
2
The cGAS–STING pathway drives type I IFN immunopathology in COVID-19
Nature|2022
542 cit.
3
Bacterial gasdermins reveal an ancient mechanism of cell death
Science|2022
266 cit.
4
A non-canonical cGAS–STING–PERK pathway facilitates the translational program critical for senescence and organ fibrosis
Nature Cell Biology|2022
256 cit.
5
Phage anti-CBASS and anti-Pycsar nucleases subvert bacterial immunity
Nature|2022
189 cit.
6
Clathrin-associated AP-1 controls termination of STING signalling
Nature|2022
149 cit.
7
Cryo-EM structure of an active bacterial TIR–STING filament complex
Nature|2022
126 cit.
8
Boron encapsulated in a liposome can be used for combinational neutron capture therapy
Nature Communications|2022
122 cit.
9
A large-scale systematic survey reveals recurring molecular features of public antibody responses to SARS-CoV-2
Immunity|2022
121 cit.
10
Structural basis of Gabija anti-phage defence and viral immune evasion
Nature|2023
116 cit.

Current Senior Leaders

Wrote the book, still writing it

Researchers

1
Zhijian J. Chen
Howard Hughes Medical Institute
2
Tadatsugu Taniguchi
The University of Tokyo
3
Shizuo Akira
Kunsan National University
4
Vishva M. Dixit
Molecular Oncology (United States)
5
Glen N. Barber
Immunité et Cancer
6
Adolfo García‐Sastre
Office of Infectious Diseases
7
Michael Karin
Discovery Institute
8
Hong‐Bing Shu
Wuhan University
9
Takashi Fujita
Gifu Prefectural Tajimi Hospital
10
Thirumala‐Devi Kanneganti
St. Jude Children's Research Hospital

Papers

1
Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway
Science|2012
4.8k cit.
2
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses
Nature Immunology|2004
3.9k cit.
3
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
Nature|2006
3.8k cit.
4
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
Nature|2015
3.7k cit.
5
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
Nature|2008
3.5k cit.
6
Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the <i>Lps</i> Gene Product
The Journal of Immunology|1999
3.4k cit.
7
Differential Roles of TLR2 and TLR4 in Recognition of Gram-Negative and Gram-Positive Bacterial Cell Wall Components
Immunity|1999
3.4k cit.
8
Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3
Cell|2005
3.3k cit.
9
Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway
Science|2003
3.2k cit.
10
FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex
Cell|1996
3.1k cit.

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