Leaderboards/Drug Transport and Resistance Mechanisms

Drug Transport and Resistance Mechanisms

Last updated July 15, 2026

Rising Stars

Fresh ink, massive impact

Researchers

1
Yuanheng Yang
Central South University
2
Bipin Rimal
Pennsylvania State University
3
Sumaiyah K. Rehman
Princess Margaret Cancer Centre
4
Junliang Kuang
Shanghai Sixth People's Hospital
5
Ipsita Mohanty
University of California San Diego
6
Yuma Saimoto
Kyushu University
7
Akshay Sabnis
Imperial College London
8
Tae Won
Cornell University
9
Haixu Jiang
Beijing University of Chinese Medicine
10
Chuan’ai Chen
Nankai University

Papers

1
Bile salt hydrolase catalyses formation of amine-conjugated bile acids
Nature|2024
205 cit.
2
The underappreciated diversity of bile acid modifications
Cell|2024
190 cit.
3
Publication in Science (2025) [105 citations, W4409176469]
Science|2025
105 cit.
4
Publication in Journal of Controlled Release (2025) [53 citations, W4409316752]
Journal of Controlled Release|2025
53 cit.
5
Investigating regional-specific gut microbial distribution: an uncharted territory in disease therapeutics
Protein & Cell|2024
4 cit.
6
Non-conjugative plasmids limit their mobility to persist in nature
Cell Reports|2025
2 cit.
7
Publication in Osteoarthritis and Cartilage (2024) [W4394927894]
Osteoarthritis and Cartilage|2024
0 cit.
8
Publication in Chinese Medicine (2026) [W7162120586]
Chinese Medicine|2026
0 cit.
9
Publication in Figshare (2026) [W7162186236]
Figshare|2026
0 cit.
10
Publication in Figshare (2026) [W7162191037]
Figshare|2026
0 cit.

Emerging Leaders

Drafting the new consensus

Researchers

1
Jun R. Huh
Harvard University
2
A. Sloan Devlin
Harvard University
3
Changtao Jiang
Peking University
4
Kevin J. Washicosky
Massachusetts General Hospital
5
Se Hoon Choi
MaineGeneral Medical Center
6
Tove Sjögren
AstraZeneca (Brazil)
7
Inho Choi
Yeungnam University
8
Youwei Ai
Jinan University
9
Casey M. Theriot
North Carolina State University
10
Lili Sheng
First Affiliated Hospital of Wannan Medical College

Papers

1
Human gut bacteria produce ΤΗ17-modulating bile acid metabolites
Nature|2022
552 cit.
2
The biochemical pathways of apoptotic, necroptotic, pyroptotic, and ferroptotic cell death
Molecular Cell|2024
372 cit.
3
Gut symbionts alleviate MASH through a secondary bile acid biosynthetic pathway
Cell|2024
275 cit.
4
Gut bacteria alleviate smoking-related NASH by degrading gut nicotine
Nature|2022
211 cit.
5
Bile salt hydrolases shape the bile acid landscape and restrict Clostridioides difficile growth in the murine gut
Nature Microbiology|2023
169 cit.
6
Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target
Science|2023
166 cit.
7
Irisin reduces amyloid-β by inducing the release of neprilysin from astrocytes following downregulation of ERK-STAT3 signaling
Neuron|2023
111 cit.
8
A biosynthetic pathway for the selective sulfonation of steroidal metabolites by human gut bacteria
Nature Microbiology|2022
88 cit.
9
Gut bacteria convert glucocorticoids into progestins in the presence of hydrogen gas
Cell|2024
88 cit.
10
A microbial amino-acid-conjugated bile acid, tryptophan-cholic acid, improves glucose homeostasis via the orphan receptor MRGPRE
Cell|2025
46 cit.

Current Senior Leaders

Wrote the book, still writing it

Researchers

1
Yuichi Sugiyama
ShanghaiTech University
2
Frank J. Gonzalez
National Cancer Institute
3
David J. Mangelsdorf
Southwestern Medical Center
4
Michael M. Gottesman
National Cancer Institute
5
Curtis D. Klaassen
University of Kansas Medical Center
6
Alfred H. Schinkel
Oncode Institute
7
Victor Ling
BC Cancer Agency
8
Steven A. Kliewer
Southwestern Medical Center
9
Per Artursson
Uppsala University
10
Susan E. Bates
The Nature Conservancy

Papers

1
An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)
Journal of Biological Chemistry|1995
3.6k cit.
2
A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants
Biochimica et Biophysica Acta (BBA) - Biomembranes|1976
3.3k cit.
3
A "Silent" Polymorphism in the <i>MDR</i> 1 Gene Changes Substrate Specificity
Science|2006
2.5k cit.
4
Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs
Cell|1994
2.3k cit.
5
Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ
Proceedings of the National Academy of Sciences|1997
2.2k cit.
6
A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation
Cell|1995
2k cit.
7
A Regulatory Cascade of the Nuclear Receptors FXR, SHP-1, and LRH-1 Represses Bile Acid Biosynthesis
Molecular Cell|2000
1.9k cit.
8
Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells
Biochemical and Biophysical Research Communications|1991
1.9k cit.
9
Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis
Cell Metabolism|2005
1.8k cit.
10
Targeted Disruption of the Nuclear Receptor FXR/BAR Impairs Bile Acid and Lipid Homeostasis
Cell|2000
1.8k cit.

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