Leaderboards/DNA Repair Mechanisms

DNA Repair Mechanisms

Last updated July 15, 2026

Rising Stars

Fresh ink, massive impact

Researchers

1
Sumaiyah K. Rehman
Princess Margaret Cancer Centre
2
Michalis Petropoulos
University of Bern
3
Léa Montégut
Icahn School of Medicine at Mount Sinai
4
Ruben M. Drews
GlaxoSmithKline (United Kingdom)
5
Nagaraja Chappidi
University of Zurich
6
Diana Zatreanu
Institute of Cancer Research
7
Marjolein van Sluis
Erasmus MC
8
Antoine Simoneau
Io Therapeutics (United States)
9
Sigrid Uxa
University Hospital Leipzig
10
Ondrej Beláň
Brigham and Women's Hospital

Papers

1
Transcription–replication conflicts underlie sensitivity to PARP inhibitors
Nature|2024
181 cit.
2
Publication in Molecular Cancer (2024) [159 citations, W4397044051]
Molecular Cancer|2024
159 cit.
3
Publication in Cell (2024) [154 citations, W4391542423]
Cell|2024
154 cit.
4
Transcription-coupled DNA–protein crosslink repair by CSB and CRL4CSA-mediated degradation
Nature Cell Biology|2024
50 cit.
5
Publication in Molecular Cancer (2024) [24 citations, W4402321108]
Molecular Cancer|2024
24 cit.
6
Characterization of TNG348: A Selective, Allosteric USP1 Inhibitor That Synergizes with PARP Inhibitors in Tumors with Homologous Recombination Deficiency
Molecular Cancer Therapeutics|2025
18 cit.
7
Publication in OncoImmunology (2024) [16 citations, W4403190877]
OncoImmunology|2024
16 cit.
8
Publication in Proceedings of the National Academy of Sciences (2025) [12 citations, W4412073672]
Proceedings of the National Academy of Sciences|2025
12 cit.
9
Publication in OncoImmunology (2025) [6 citations, W4412034547]
OncoImmunology|2025
6 cit.
10
Publication in Nature Reviews Molecular Cell Biology (2025) [6 citations, W4416329903]
Nature Reviews Molecular Cell Biology|2025
6 cit.

Emerging Leaders

Drafting the new consensus

Researchers

1
Francesca Cavalcanti
National Academies of Sciences, Engineering, and Medicine
2
Joseph T.P. Yeeles
MRC Laboratory of Molecular Biology
3
Matthias Altmeyer
University of Zurich
4
Alberto Ciccia
Cancer Genetics (United States)
5
Piel Matthieu
Université Paris Sciences et Lettres
6
Chun-Long Chen
Centre National de la Recherche Scientifique
7
Benjamin E. Gross
Memorial Sloan Kettering Cancer Center
8
Moriah G. Nissan
Van Andel Institute
9
Jukka Kallijärvi
University of Helsinki
10
Zuzana Hořejšı́
Queen Mary University of London

Papers

1
Fast and efficient DNA replication with purified human proteins
Nature|2022
123 cit.
2
SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion
Cell|2024
93 cit.
3
Phase separation properties of RPA combine high-affinity ssDNA binding with dynamic condensate functions at telomeres
Nature Structural & Molecular Biology|2023
81 cit.
4
How Pol α-primase is targeted to replisomes to prime eukaryotic DNA replication
Molecular Cell|2023
81 cit.
5
OKseqHMM: a genome-wide replication fork directionality analysis toolkit
Nucleic Acids Research|2022
37 cit.
6
Structural basis for processive daughter-strand synthesis and proofreading by the human leading-strand DNA polymerase Pol ε
Nature Structural & Molecular Biology|2024
31 cit.
7
Kronos scRT: a uniform framework for single-cell replication timing analysis
Nature Communications|2022
29 cit.
8
Mitochondrial complex III deficiency drives c-MYC overexpression and illicit cell cycle entry leading to senescence and segmental progeria
Nature Communications|2023
23 cit.
9
The Role of Mitochondrial Copy Number in Neurodegenerative Diseases: Present Insights and Future Directions
International Journal of Molecular Sciences|2024
22 cit.
10
Mechanisms controlling replication fork stalling and collapse at topoisomerase 1 cleavage complexes
Molecular Cell|2024
18 cit.

Current Senior Leaders

Wrote the book, still writing it

Researchers

1
Stephen P. Jackson
University of Cambridge
2
Stephen J. Elledge
Howard Hughes Medical Institute
3
Bruce Stillman
Cold Spring Harbor Laboratory
4
Titia de Lange
Rockefeller University
5
Maria Jasin
Memorial Sloan Kettering Cancer Center
6
Bert Vogelstein
Johns Hopkins University
7
James E. Haber
Brandeis University
8
Michael R. Stratton
Wellcome Sanger Institute
9
Stephen C. West
The Francis Crick Institute
10
Vilhelm A. Bohr
University of Copenhagen

Papers

1
A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity
Analytical Biochemistry|1983
25.2k cit.
2
Signatures of mutational processes in human cancer
Nature|2013
10.1k cit.
3
Genetic Alterations during Colorectal-Tumor Development
New England Journal of Medicine|1988
6.8k cit.
4
Surfing the p53 network
Nature|2000
6.6k cit.
5
Identification of the breast cancer susceptibility gene BRCA2
Nature|1995
3.7k cit.
6
A simplified system for generating recombinant adenoviruses
Proceedings of the National Academy of Sciences|1998
3.2k cit.
7
Patterns of somatic mutation in human cancer genomes
Nature|2007
3.1k cit.
8
ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage
Science|2007
3.1k cit.
9
The Genomic Landscapes of Human Breast and Colorectal Cancers
Science|2007
2.8k cit.
10
Requirement for p53 and p21 to Sustain G <sub>2</sub> Arrest After DNA Damage
Science|1998
2.8k cit.

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